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	<title>Comments on: House &#8211; Episode 10 (Season 2): &#8220;Failure to Communicate&#8221;</title>
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	<description>a blog of medicine, comics, television, science and other fun stuff</description>
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		<title>By: Gabriela</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-1159634</link>
		<dc:creator>Gabriela</dc:creator>
		<pubDate>Thu, 12 Jan 2012 18:19:01 +0000</pubDate>
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		<description>I’m not certain how the malaria caused the aphasia — a stroke maybe?

Forgive me if I&#039;m wrong here, the way I understood it was that the aphasia was caused because he hit his head quite nastily. 
Also, I&#039;m not a writer either but this episode pricked my interest and I did some research. I found that polyglots who suffer aphasia sometimes forget their mother tongue and start speaking in a language they learnt later. This would have been an interesting twist and a chance for House to show off since he is himself a polyglot if the patient had been multilingual as well. It would have made sense of the decoding part as well.</description>
		<content:encoded><![CDATA[<p>I’m not certain how the malaria caused the aphasia — a stroke maybe?</p>
<p>Forgive me if I&#8217;m wrong here, the way I understood it was that the aphasia was caused because he hit his head quite nastily.<br />
Also, I&#8217;m not a writer either but this episode pricked my interest and I did some research. I found that polyglots who suffer aphasia sometimes forget their mother tongue and start speaking in a language they learnt later. This would have been an interesting twist and a chance for House to show off since he is himself a polyglot if the patient had been multilingual as well. It would have made sense of the decoding part as well.</p>
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		<title>By: Mr. John Johnson</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-1036855</link>
		<dc:creator>Mr. John Johnson</dc:creator>
		<pubDate>Fri, 22 Apr 2011 00:11:57 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-1036855</guid>
		<description>Hey,
love your reviews by the way, keep them coming untill house goes of.
i dont know how long its bin since you posted this review, but i recon its about 5 years ago?
i know its a long time ago but i wanted to correct you on something, or if i&#039;m wrong, you correct me on my correction of your correction of house (Im getting a headache)

you said that the decode the aphasia thing was &quot;ludicrous&quot;
So i looked it up
cause i figured that its not to much of a long shot that this was possible

so i googled, used about 40 minuts and i came over this

http://books.google.no/books?id=0asXiTckqp0C&amp;pg=PA71&amp;lpg=PA71&amp;dq=aphasia+nife+instead+of+spoon&amp;source=bl&amp;ots=DZJqehvVPl&amp;sig=9yM2Ws54Om-LFfqweVurQfYMFJM&amp;hl=no&amp;ei=rMOwTaDpL5WW4gaIoIijDA&amp;sa=X&amp;oi=book_result&amp;ct=result&amp;resnum=1&amp;ved=0CBgQ6AEwAA#v=onepage&amp;q&amp;f=false

read the part that starts : When paitients says words that ryhmes with the correct......

i hope the link work, if not email me

i wanned to find out wether or not it is possible for a person with a serton type of aphesia to choose a word close in meaning as the word they wont like &quot;spoon&quot; instead of &quot;Knife&quot;
or by ryme like, as house use as an exaple &quot;lable&quot; instead of &quot;table&quot;

so my correction or your review is

it should in theory be possible to &quot;decode the aphasia&quot;

My email: Sigurdbergsvela@gmail.com
please Give me an answer, i would be delightet to hear wether i&#039;m right or not

(I&#039;m from norway and have dyslexia, please ignore the spilling errors)</description>
		<content:encoded><![CDATA[<p>Hey,<br />
love your reviews by the way, keep them coming untill house goes of.<br />
i dont know how long its bin since you posted this review, but i recon its about 5 years ago?<br />
i know its a long time ago but i wanted to correct you on something, or if i&#8217;m wrong, you correct me on my correction of your correction of house (Im getting a headache)</p>
<p>you said that the decode the aphasia thing was &#8220;ludicrous&#8221;<br />
So i looked it up<br />
cause i figured that its not to much of a long shot that this was possible</p>
<p>so i googled, used about 40 minuts and i came over this</p>
<p><a href="http://books.google.no/books?id=0asXiTckqp0C&amp;pg=PA71&amp;lpg=PA71&amp;dq=aphasia+nife+instead+of+spoon&amp;source=bl&amp;ots=DZJqehvVPl&amp;sig=9yM2Ws54Om-LFfqweVurQfYMFJM&amp;hl=no&amp;ei=rMOwTaDpL5WW4gaIoIijDA&amp;sa=X&amp;oi=book_result&amp;ct=result&amp;resnum=1&amp;ved=0CBgQ6AEwAA#v=onepage&amp;q&amp;f=false" rel="nofollow">http://books.google.no/books?id=0asXiTckqp0C&amp;pg=PA71&amp;lpg=PA71&amp;dq=aphasia+nife+instead+of+spoon&amp;source=bl&amp;ots=DZJqehvVPl&amp;sig=9yM2Ws54Om-LFfqweVurQfYMFJM&amp;hl=no&amp;ei=rMOwTaDpL5WW4gaIoIijDA&amp;sa=X&amp;oi=book_result&amp;ct=result&amp;resnum=1&amp;ved=0CBgQ6AEwAA#v=onepage&amp;q&amp;f=false</a></p>
<p>read the part that starts : When paitients says words that ryhmes with the correct&#8230;&#8230;</p>
<p>i hope the link work, if not email me</p>
<p>i wanned to find out wether or not it is possible for a person with a serton type of aphesia to choose a word close in meaning as the word they wont like &#8220;spoon&#8221; instead of &#8220;Knife&#8221;<br />
or by ryme like, as house use as an exaple &#8220;lable&#8221; instead of &#8220;table&#8221;</p>
<p>so my correction or your review is</p>
<p>it should in theory be possible to &#8220;decode the aphasia&#8221;</p>
<p>My email: <a href="mailto:Sigurdbergsvela@gmail.com">Sigurdbergsvela@gmail.com</a><br />
please Give me an answer, i would be delightet to hear wether i&#8217;m right or not</p>
<p>(I&#8217;m from norway and have dyslexia, please ignore the spilling errors)</p>
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		<title>By: William Westbrook</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-1005820</link>
		<dc:creator>William Westbrook</dc:creator>
		<pubDate>Fri, 11 Feb 2011 09:53:15 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-1005820</guid>
		<description>This has been bothering me for five years: No one living in greater Princeton would fly to Baltimore. The train takes less than two hours.</description>
		<content:encoded><![CDATA[<p>This has been bothering me for five years: No one living in greater Princeton would fly to Baltimore. The train takes less than two hours.</p>
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		<title>By: NeuroMind</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-1001505</link>
		<dc:creator>NeuroMind</dc:creator>
		<pubDate>Fri, 28 Jan 2011 08:14:11 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-1001505</guid>
		<description>I liked the episode although there were a couple of mistakes as in every episode. First I thought about a brain abcess (hence the cyclic fever) when they mentioned he probably was on drugs since HIV is a riskfactor for a toxoplasmosis infection. You should&#039;ve seen that on the MRI though. PML also crossed my mind but the fever didn&#039;t really fit. 

The biggest mistake was that the MRI didn&#039;t show any signs of infarction or hemorrhage. In cerebral malaria there&#039;s occlusion of the small vessels causing microbleeds (as in vasculitis) and multiple infarctions. In the episode they only checked the T2 series, while they should&#039;ve made DWI series and SWI. 
On DWI, in respect to a clinical aphasia, there HAVE to be hyperintense lesions in the corresponding areas. On SWI you&#039;d clearly see the microbleeds. When you&#039;re thinking about recent infarction only T2 is obviously not enough.

As people mentioned before, the aphasia was of a strange type. 
It was a typical wortsalat like in Wernicke, but the comprehension was completely intact.</description>
		<content:encoded><![CDATA[<p>I liked the episode although there were a couple of mistakes as in every episode. First I thought about a brain abcess (hence the cyclic fever) when they mentioned he probably was on drugs since HIV is a riskfactor for a toxoplasmosis infection. You should&#8217;ve seen that on the MRI though. PML also crossed my mind but the fever didn&#8217;t really fit. </p>
<p>The biggest mistake was that the MRI didn&#8217;t show any signs of infarction or hemorrhage. In cerebral malaria there&#8217;s occlusion of the small vessels causing microbleeds (as in vasculitis) and multiple infarctions. In the episode they only checked the T2 series, while they should&#8217;ve made DWI series and SWI.<br />
On DWI, in respect to a clinical aphasia, there HAVE to be hyperintense lesions in the corresponding areas. On SWI you&#8217;d clearly see the microbleeds. When you&#8217;re thinking about recent infarction only T2 is obviously not enough.</p>
<p>As people mentioned before, the aphasia was of a strange type.<br />
It was a typical wortsalat like in Wernicke, but the comprehension was completely intact.</p>
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		<title>By: Diseraph</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-848621</link>
		<dc:creator>Diseraph</dc:creator>
		<pubDate>Mon, 17 May 2010 02:34:03 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-848621</guid>
		<description>No one mentioned this before and I know it is late but, Foreman says close to the end that &quot;If someone along the line had bothered to look at the sample instead of running tests they would have seen the parasites.&quot; I thought pathologists were trained to look at the sample at a macro-level, record its colouring that sort of thing. Of course being that the doctors were doing all the work themselves would explain it but I think the comment was unnecessary and fairly derogatory towards pathology staff.</description>
		<content:encoded><![CDATA[<p>No one mentioned this before and I know it is late but, Foreman says close to the end that &#8220;If someone along the line had bothered to look at the sample instead of running tests they would have seen the parasites.&#8221; I thought pathologists were trained to look at the sample at a macro-level, record its colouring that sort of thing. Of course being that the doctors were doing all the work themselves would explain it but I think the comment was unnecessary and fairly derogatory towards pathology staff.</p>
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		<title>By: Grant</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-847635</link>
		<dc:creator>Grant</dc:creator>
		<pubDate>Sat, 15 May 2010 19:41:28 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-847635</guid>
		<description>I&#039;ve been doing psycholinguistic analysis of stroke aphasia syndromes full-time for the past 4 years, funded by the NIH. So, it&#039;s actually my job to &quot;decode&quot; aphasia, although we do this in a controlled laboratory setting, as opposed to analyzing spontaneous communications (which is indeed quite difficult, often impossible, but not necessarily &quot;ludicrous&quot;). I was thrilled to see a House episode about aphasia, especially since House&#039;s following quote is almost a direct reference to our work: &quot;A fluent aphasic retrieves words that are stored somewhere close to the one he wants. They can be filed by sounds or by meaning. So if he wants to say table, he could say... label, or he could say chair. Or he could just say Jabberwocky, there&#039;s no way to tell.&quot; Actually, analysis of speech errors, and these observations in particular, has been around for a long time, perhaps most notably by Freud. Our research group has gone some way to provide a scientific explanation of how these errors arise from neurological dysfunction. (Here is a great slideshow/lecture by my collaborator and highly influential language researcher, Gary Dell, from University of Illinois - www.hstalks.com/review/HST105/2504.htm)

Regarding this particular case, as with most of House&#039;s cases, if this presentation exists at all, it is quite rare. As has been mentioned already, this type of fluent jargon production, particularly in the context of being unaware of one&#039;s own errors, typically is accompanied by comprehension deficits. Language is an extremely complex integration of cognitive processes occurring in a parallel, interactive fashion. Many of the processes can be independently damaged, while sparing others, resulting in characteristic patterns of language performance. These patterns of performance have been classified by clinicians, and the most commonly recognized forms include Wernicke&#039;s, Broca&#039;s, Conduction, Anomic, Transcortical Sensory, Transcortical Motor, and Global aphasia. Wernicke&#039;s and Broca&#039;s aphasia, named for the neurologists who described the characteristic symptoms, were the first of these terms developed, and because of the stark contrast between them, these are the ones you may learn about in a Psych 101 class. In the real world however, the contrasts between diagnoses may not be quite so obvious.

These terms were developed about 100 years before clinical imaging (i.e. PET, CT, MRI) was available, using post-mortem dissection. The idea was to infer the location of brain damage from behavioral symptoms (e.g. Broca&#039;s = anterior, Wernicke&#039;s = posterior, Conduction = disconnection of anterior and posterior), and for the most part, these inferences work. The important thing to remember though is that these are syndromes, representing quite a bit of variability of symptom types and severity. For comparison, consider a patient with autism. This patient may fall anywhere along a spectrum of disorder, but the term itself carries a lot of useful stereotypical information. Many researchers in my field believe we should abandon the clinical terms for aphasia altogether, because they are often too imprecise for our purposes (e.g. localizing a single cognitive process). I disagree, because these terms provide a concise description for clinical purposes; nevertheless, one should be careful not to &quot;pigeonhole&quot; patients based on their diagnosis, especially since symptoms can vary over time through spontaneous recovery, or even over the course of a single day.

Overall, I thought it was a great episode, and I was happy to find such an interesting discussion about this topic.</description>
		<content:encoded><![CDATA[<p>I&#8217;ve been doing psycholinguistic analysis of stroke aphasia syndromes full-time for the past 4 years, funded by the NIH. So, it&#8217;s actually my job to &#8220;decode&#8221; aphasia, although we do this in a controlled laboratory setting, as opposed to analyzing spontaneous communications (which is indeed quite difficult, often impossible, but not necessarily &#8220;ludicrous&#8221;). I was thrilled to see a House episode about aphasia, especially since House&#8217;s following quote is almost a direct reference to our work: &#8220;A fluent aphasic retrieves words that are stored somewhere close to the one he wants. They can be filed by sounds or by meaning. So if he wants to say table, he could say&#8230; label, or he could say chair. Or he could just say Jabberwocky, there&#8217;s no way to tell.&#8221; Actually, analysis of speech errors, and these observations in particular, has been around for a long time, perhaps most notably by Freud. Our research group has gone some way to provide a scientific explanation of how these errors arise from neurological dysfunction. (Here is a great slideshow/lecture by my collaborator and highly influential language researcher, Gary Dell, from University of Illinois &#8211; <a href="http://www.hstalks.com/review/HST105/2504.htm" rel="nofollow">http://www.hstalks.com/review/HST105/2504.htm</a>)</p>
<p>Regarding this particular case, as with most of House&#8217;s cases, if this presentation exists at all, it is quite rare. As has been mentioned already, this type of fluent jargon production, particularly in the context of being unaware of one&#8217;s own errors, typically is accompanied by comprehension deficits. Language is an extremely complex integration of cognitive processes occurring in a parallel, interactive fashion. Many of the processes can be independently damaged, while sparing others, resulting in characteristic patterns of language performance. These patterns of performance have been classified by clinicians, and the most commonly recognized forms include Wernicke&#8217;s, Broca&#8217;s, Conduction, Anomic, Transcortical Sensory, Transcortical Motor, and Global aphasia. Wernicke&#8217;s and Broca&#8217;s aphasia, named for the neurologists who described the characteristic symptoms, were the first of these terms developed, and because of the stark contrast between them, these are the ones you may learn about in a Psych 101 class. In the real world however, the contrasts between diagnoses may not be quite so obvious.</p>
<p>These terms were developed about 100 years before clinical imaging (i.e. PET, CT, MRI) was available, using post-mortem dissection. The idea was to infer the location of brain damage from behavioral symptoms (e.g. Broca&#8217;s = anterior, Wernicke&#8217;s = posterior, Conduction = disconnection of anterior and posterior), and for the most part, these inferences work. The important thing to remember though is that these are syndromes, representing quite a bit of variability of symptom types and severity. For comparison, consider a patient with autism. This patient may fall anywhere along a spectrum of disorder, but the term itself carries a lot of useful stereotypical information. Many researchers in my field believe we should abandon the clinical terms for aphasia altogether, because they are often too imprecise for our purposes (e.g. localizing a single cognitive process). I disagree, because these terms provide a concise description for clinical purposes; nevertheless, one should be careful not to &#8220;pigeonhole&#8221; patients based on their diagnosis, especially since symptoms can vary over time through spontaneous recovery, or even over the course of a single day.</p>
<p>Overall, I thought it was a great episode, and I was happy to find such an interesting discussion about this topic.</p>
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		<title>By: Dr. Illutionist</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-813541</link>
		<dc:creator>Dr. Illutionist</dc:creator>
		<pubDate>Sat, 17 Apr 2010 20:04:34 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-813541</guid>
		<description>Excellent Review...

But a Good episode also, House smooches  ;-)</description>
		<content:encoded><![CDATA[<p>Excellent Review&#8230;</p>
<p>But a Good episode also, House smooches  ;-)</p>
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		<title>By: Homuncula</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-773206</link>
		<dc:creator>Homuncula</dc:creator>
		<pubDate>Wed, 24 Mar 2010 02:41:39 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-773206</guid>
		<description>Hm.  I just went through a script of the epi i found online, and i see that &quot;conduction aphasia&#039; is what is suggested, not expressive aphasia.  Does that put a different spin on the discussion?</description>
		<content:encoded><![CDATA[<p>Hm.  I just went through a script of the epi i found online, and i see that &#8220;conduction aphasia&#8217; is what is suggested, not expressive aphasia.  Does that put a different spin on the discussion?</p>
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		<title>By: Kathryn</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-729397</link>
		<dc:creator>Kathryn</dc:creator>
		<pubDate>Tue, 23 Feb 2010 23:50:20 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-729397</guid>
		<description>This episode actually has a pretty big medical error. There are two types of aphasia, Broca&#039;s and Wernicke&#039;s. Has full ability to form words, and complete understanding of what people are telling him, but does not realize that he is using the wrong words to answer. These symptoms do not all fall under one form of aphasia. In Broca&#039;s aphasia, the patient will understand what is being said to him, but will lack to ability to form the proper words to answer, and will be fully aware, and very frustrated. In Wernicke&#039;s aphasia, the patient will have no understanding of what is being told/asked of them, but will have the ability to form words, albeit the wrong ones, and will not realize that there is anything wrong with their speech. The patient in this episode has some sort of weird mix of the two, which does not exist.

Not saying it is a bad episode though, I think it is hilarious.</description>
		<content:encoded><![CDATA[<p>This episode actually has a pretty big medical error. There are two types of aphasia, Broca&#8217;s and Wernicke&#8217;s. Has full ability to form words, and complete understanding of what people are telling him, but does not realize that he is using the wrong words to answer. These symptoms do not all fall under one form of aphasia. In Broca&#8217;s aphasia, the patient will understand what is being said to him, but will lack to ability to form the proper words to answer, and will be fully aware, and very frustrated. In Wernicke&#8217;s aphasia, the patient will have no understanding of what is being told/asked of them, but will have the ability to form words, albeit the wrong ones, and will not realize that there is anything wrong with their speech. The patient in this episode has some sort of weird mix of the two, which does not exist.</p>
<p>Not saying it is a bad episode though, I think it is hilarious.</p>
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		<title>By: Kate</title>
		<link>http://www.politedissent.com/archives/1077/comment-page-1#comment-697386</link>
		<dc:creator>Kate</dc:creator>
		<pubDate>Sun, 31 Jan 2010 05:46:00 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/archives/1077#comment-697386</guid>
		<description>I can&#039;t imagine why anyone would think &quot;weight loss&quot; when seeing Topamax. It&#039;s used very often for bipolar disorder (though Trileptal is used more, because it is a derivative of Topamax and is less likely to cause drops in sodium and low white blood cell count) despite that being an off-label use. Seeing that would, I&#039;d imagine, make a doctor think either epilepsy or bipolar. I can&#039;t imagine why they wouldn&#039;t think of it sooner.</description>
		<content:encoded><![CDATA[<p>I can&#8217;t imagine why anyone would think &#8220;weight loss&#8221; when seeing Topamax. It&#8217;s used very often for bipolar disorder (though Trileptal is used more, because it is a derivative of Topamax and is less likely to cause drops in sodium and low white blood cell count) despite that being an off-label use. Seeing that would, I&#8217;d imagine, make a doctor think either epilepsy or bipolar. I can&#8217;t imagine why they wouldn&#8217;t think of it sooner.</p>
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