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	<title>Comments on: House &#8212; Episode 16 (Season 5): &#8220;The Softer Side&#8221;</title>
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	<description>a blog of medicine, comics, television, science and other fun stuff</description>
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		<title>By: ecoli</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-1116888</link>
		<dc:creator>ecoli</dc:creator>
		<pubDate>Mon, 17 Oct 2011 18:42:46 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-1116888</guid>
		<description>Not too much to note on the medicine, but a significant ontological point: Why would chimerism lead to intersexuality? The Y and X act only through one organ - the testicle - so unless there was something wrong somewhere else in the DNA, the XX-bearing cells would be still be masculinized by FGF8 or FGF9 and androgens, since it&#039;s only via the precursors of the gonads that the Y acts. Also, even a chimeric gonad should have enough Y-bearing cells to produce testosterone, no replacement would be needed.</description>
		<content:encoded><![CDATA[<p>Not too much to note on the medicine, but a significant ontological point: Why would chimerism lead to intersexuality? The Y and X act only through one organ &#8211; the testicle &#8211; so unless there was something wrong somewhere else in the DNA, the XX-bearing cells would be still be masculinized by FGF8 or FGF9 and androgens, since it&#8217;s only via the precursors of the gonads that the Y acts. Also, even a chimeric gonad should have enough Y-bearing cells to produce testosterone, no replacement would be needed.</p>
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		<title>By: Tommy Turtle</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-1084909</link>
		<dc:creator>Tommy Turtle</dc:creator>
		<pubDate>Fri, 29 Jul 2011 08:06:10 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-1084909</guid>
		<description>@ PharmStu and Everyone Else Re: APAP and other ingredients with hydrocodone. 

My pharmacist told me that you *can* get hydrocodone alone, but for some reason, only in a brand name that naturally costs about ten times as much as the typical hydro-APAP or other cheap generics.  (This was for post-dental surgery, if you need to know.) So for such occasional, brief usages, it&#039;s much cheaper to get the combo. 

But the point about House&#039;s liver -- specific warnings against combining acetaminphen with alcohol regularly, too-- he should obtain the single-ingredient product. I&#039;m sure he can get an employee discount. ;)</description>
		<content:encoded><![CDATA[<p>@ PharmStu and Everyone Else Re: APAP and other ingredients with hydrocodone. </p>
<p>My pharmacist told me that you *can* get hydrocodone alone, but for some reason, only in a brand name that naturally costs about ten times as much as the typical hydro-APAP or other cheap generics.  (This was for post-dental surgery, if you need to know.) So for such occasional, brief usages, it&#8217;s much cheaper to get the combo. </p>
<p>But the point about House&#8217;s liver &#8212; specific warnings against combining acetaminphen with alcohol regularly, too&#8211; he should obtain the single-ingredient product. I&#8217;m sure he can get an employee discount. ;)</p>
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		<title>By: Marina</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-1004843</link>
		<dc:creator>Marina</dc:creator>
		<pubDate>Sun, 06 Feb 2011 18:43:14 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-1004843</guid>
		<description>Do you mean thirteen or foreman because you said foreteen in the 1st paragraph. (I havn&#039;t watched it yet)</description>
		<content:encoded><![CDATA[<p>Do you mean thirteen or foreman because you said foreteen in the 1st paragraph. (I havn&#8217;t watched it yet)</p>
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		<title>By: Jmo</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-835544</link>
		<dc:creator>Jmo</dc:creator>
		<pubDate>Fri, 30 Apr 2010 07:15:24 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-835544</guid>
		<description>Re: maintenance... I think methadone would be a better choice for weaning someone off heroin, because its long half life can smooth out the withdrawal. For actual maintenance, though, my personal opinion is heroin (in a controlled setting of course) because it&#039;s safer.

Also, I&#039;m with the people who say House doesn&#039;t need the pain, he&#039;s just being stubborn and needs it psychologically because it&#039;s familiar and he feels more in control. (I&#039;m sure if he gave the methadone some time he would&#039;ve returned to good ol&#039; grumpy, sarcastic, cynical House, just pain-free.)</description>
		<content:encoded><![CDATA[<p>Re: maintenance&#8230; I think methadone would be a better choice for weaning someone off heroin, because its long half life can smooth out the withdrawal. For actual maintenance, though, my personal opinion is heroin (in a controlled setting of course) because it&#8217;s safer.</p>
<p>Also, I&#8217;m with the people who say House doesn&#8217;t need the pain, he&#8217;s just being stubborn and needs it psychologically because it&#8217;s familiar and he feels more in control. (I&#8217;m sure if he gave the methadone some time he would&#8217;ve returned to good ol&#8217; grumpy, sarcastic, cynical House, just pain-free.)</p>
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		<title>By: Etellerannet</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-671403</link>
		<dc:creator>Etellerannet</dc:creator>
		<pubDate>Tue, 29 Dec 2009 04:10:10 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-671403</guid>
		<description>Hhaha.
13: &quot;There&#039;s no reason you can&#039;t do both&quot;</description>
		<content:encoded><![CDATA[<p>Hhaha.<br />
13: &#8220;There&#8217;s no reason you can&#8217;t do both&#8221;</p>
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		<title>By: Alice Moon</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-664098</link>
		<dc:creator>Alice Moon</dc:creator>
		<pubDate>Mon, 14 Dec 2009 22:30:16 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-664098</guid>
		<description>I only just saw the episode and I can&#039;t believe that supporting characters like Cuddy and Wilson, who are supposed to be intelligent and insightful themselves (plus the man&#039;s closest friends) never seem to see House&#039;s simplest actions coming. 
The prostitute? I called that one in the livingroom well before they showed the scene. I also said heroin would be the drug, several minutes before anyone else started guessing what he was on. 
I&#039;m disturbed by the team&#039;s willingness to rush headlong into the patient&#039;s room each week to give what will be one of several definitive and incorrect diagnoses. They can&#039;t wait a few hours or days to see if anything changes? Especially after this has happened repeatedly? 
My partner and I are especially irked by the scenes where a test or scan is being done and the professionals are spending more time exploring each others&#039; moral and relationship status than watching the monitor or the patient. I realize it is a convenient, quiet time to do plot work, but come on.</description>
		<content:encoded><![CDATA[<p>I only just saw the episode and I can&#8217;t believe that supporting characters like Cuddy and Wilson, who are supposed to be intelligent and insightful themselves (plus the man&#8217;s closest friends) never seem to see House&#8217;s simplest actions coming.<br />
The prostitute? I called that one in the livingroom well before they showed the scene. I also said heroin would be the drug, several minutes before anyone else started guessing what he was on.<br />
I&#8217;m disturbed by the team&#8217;s willingness to rush headlong into the patient&#8217;s room each week to give what will be one of several definitive and incorrect diagnoses. They can&#8217;t wait a few hours or days to see if anything changes? Especially after this has happened repeatedly?<br />
My partner and I are especially irked by the scenes where a test or scan is being done and the professionals are spending more time exploring each others&#8217; moral and relationship status than watching the monitor or the patient. I realize it is a convenient, quiet time to do plot work, but come on.</p>
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		<title>By: Page</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-648699</link>
		<dc:creator>Page</dc:creator>
		<pubDate>Fri, 13 Nov 2009 21:53:20 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-648699</guid>
		<description>House is my favorite show - but I was upset with this episode.  First off, everyone acted like it was terrible for House to be on Methadone.  Methadone is a wonderful drug to help get off pain meds for addicts.  My dr. got me hooked on Oxycontin.  If it wasn&#039;t for Methadone I don&#039;t know where I would be.  

You do have to be careful of the dosage you take, as well as what other meds you take with it and you can not drink alcohol.  But - if you know what you are doing - you won&#039;t have any trouble.  I think it was stupid for them to make House stop breathing like that.  That makes him seem stupid - because he is a very intellegient dr - and for him to stop breathing - he would of had to take another medication with it that causes the breathing to slow (example would be benzos such as valium, xanax, etc.).  House wouldn&#039;t be that stupid.  

Now House wasn&#039;t doing it to get off pain meds - he was doing it for pain.  It totally stopped the pain.  This could happen - as methadone is a lot stronger that what he was taking.   Also, I can&#039;t figure out why he is only taking Vicodin ES.  This is 7.5 mg.  He takes more than one at a time.  A Dr would prescribe Norco&#039;s instead if they were to prescribe the Vicodin family of narcotics.  Norco is a 10mg pill with 325 mg of tylenol in it.  Regular Vicodin tends to have bunches of tylenol in them - this effects the kidneys and liver.  That is why some dr&#039;s change to Norcos and sadly to Oxycontin.  

With House and the writers and dr&#039;s on the show being so intelligent and finding cures for most all of their cases, they take a dumb and not very bright approach to this subject.  Do your homework before you do another show with a narcotic such as Methadone.  I was very disappointed.</description>
		<content:encoded><![CDATA[<p>House is my favorite show &#8211; but I was upset with this episode.  First off, everyone acted like it was terrible for House to be on Methadone.  Methadone is a wonderful drug to help get off pain meds for addicts.  My dr. got me hooked on Oxycontin.  If it wasn&#8217;t for Methadone I don&#8217;t know where I would be.  </p>
<p>You do have to be careful of the dosage you take, as well as what other meds you take with it and you can not drink alcohol.  But &#8211; if you know what you are doing &#8211; you won&#8217;t have any trouble.  I think it was stupid for them to make House stop breathing like that.  That makes him seem stupid &#8211; because he is a very intellegient dr &#8211; and for him to stop breathing &#8211; he would of had to take another medication with it that causes the breathing to slow (example would be benzos such as valium, xanax, etc.).  House wouldn&#8217;t be that stupid.  </p>
<p>Now House wasn&#8217;t doing it to get off pain meds &#8211; he was doing it for pain.  It totally stopped the pain.  This could happen &#8211; as methadone is a lot stronger that what he was taking.   Also, I can&#8217;t figure out why he is only taking Vicodin ES.  This is 7.5 mg.  He takes more than one at a time.  A Dr would prescribe Norco&#8217;s instead if they were to prescribe the Vicodin family of narcotics.  Norco is a 10mg pill with 325 mg of tylenol in it.  Regular Vicodin tends to have bunches of tylenol in them &#8211; this effects the kidneys and liver.  That is why some dr&#8217;s change to Norcos and sadly to Oxycontin.  </p>
<p>With House and the writers and dr&#8217;s on the show being so intelligent and finding cures for most all of their cases, they take a dumb and not very bright approach to this subject.  Do your homework before you do another show with a narcotic such as Methadone.  I was very disappointed.</p>
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		<title>By: Passerby</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-647033</link>
		<dc:creator>Passerby</dc:creator>
		<pubDate>Mon, 09 Nov 2009 22:00:43 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-647033</guid>
		<description>Dr House uses pain to be perpetually grumpy.  According to recent study reports, grumpy is good, if you want to be especially attentive.   The character. like the actor who plays him, is also clinically depressed.

In the LaLa Land of this program, nobody ever worries about the costs rung by countless tests, invasive procedures, and snap ordering of various drugs.  Not one peep when unnecessary surgeries are performed.  Ethics issues arise when the hospital administrator claims reputation damage from Dr Foreman&#039;s lapse in giving Thirteen the test drug, but  nobody bats an eye when one or more team members breaks into the patients home to &#039;investigate&#039;.  Never is the patient asked permission.

A perpetually annoying aspect is that an entire team is assigned to work with just 1 or 2 patients at a time.  Equally disturbing is the fact that the team is shown constantly performing mundane nursing actions for the central character patient in each episode, which we know is never done by any doctor, let alone by many nurses in a busy ER ward.

Now wouldn&#039;t it be interesting if the cast were to face a real time crisis, say...a mobbed ER waiting room full of sick patients, many or most of whom are suffering from this pandemic influenza.   Contrast the dilemma of a harried and short-handed staff trying to sort through who is to be treated and whom to send home.  

That is what our hospitals are facing presently.  And the situation is going to get worse, much worse, in the next 60-90 days.</description>
		<content:encoded><![CDATA[<p>Dr House uses pain to be perpetually grumpy.  According to recent study reports, grumpy is good, if you want to be especially attentive.   The character. like the actor who plays him, is also clinically depressed.</p>
<p>In the LaLa Land of this program, nobody ever worries about the costs rung by countless tests, invasive procedures, and snap ordering of various drugs.  Not one peep when unnecessary surgeries are performed.  Ethics issues arise when the hospital administrator claims reputation damage from Dr Foreman&#8217;s lapse in giving Thirteen the test drug, but  nobody bats an eye when one or more team members breaks into the patients home to &#8216;investigate&#8217;.  Never is the patient asked permission.</p>
<p>A perpetually annoying aspect is that an entire team is assigned to work with just 1 or 2 patients at a time.  Equally disturbing is the fact that the team is shown constantly performing mundane nursing actions for the central character patient in each episode, which we know is never done by any doctor, let alone by many nurses in a busy ER ward.</p>
<p>Now wouldn&#8217;t it be interesting if the cast were to face a real time crisis, say&#8230;a mobbed ER waiting room full of sick patients, many or most of whom are suffering from this pandemic influenza.   Contrast the dilemma of a harried and short-handed staff trying to sort through who is to be treated and whom to send home.  </p>
<p>That is what our hospitals are facing presently.  And the situation is going to get worse, much worse, in the next 60-90 days.</p>
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		<title>By: Anne</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-567273</link>
		<dc:creator>Anne</dc:creator>
		<pubDate>Wed, 22 Jul 2009 21:46:37 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-567273</guid>
		<description>Talking about pain and whether House really needs it for his work - i think it&#039;s indeed just in his head. An idea that something just has to be wrong so you won&#039;t relax too much, or that you always must pay for what you have. A superstition - why not? With all his analytical mind he&#039;s a human being. Then, again, there&#039;s a fear of changing. 
My example doesn&#039;t really fit here but once i had psychological problems,nervous breakdowns and all (i&#039;m not a doctor and i don&#039;t know terminology - i&#039;m an artist) and was afraid that if i&#039;ll get rid of them i won&#039;t be myself anymore.  They were a considerable part of my life and somehow even helped me to carry on. Funnily, now that i&#039;m fine i rarely want to paint. And it&#039;s just in the head - like i don&#039;t believe things should be  this way.
(i sound like a psycho, do i? or a typical artist))
 We don&#039;t know what helped  him to maintain that imaginary balance before the infarction but there must&#039;ve been something, some personal problems, anyway -  i&#039;d rather believe it was so than that the screenwriters forgot  how to write.</description>
		<content:encoded><![CDATA[<p>Talking about pain and whether House really needs it for his work &#8211; i think it&#8217;s indeed just in his head. An idea that something just has to be wrong so you won&#8217;t relax too much, or that you always must pay for what you have. A superstition &#8211; why not? With all his analytical mind he&#8217;s a human being. Then, again, there&#8217;s a fear of changing.<br />
My example doesn&#8217;t really fit here but once i had psychological problems,nervous breakdowns and all (i&#8217;m not a doctor and i don&#8217;t know terminology &#8211; i&#8217;m an artist) and was afraid that if i&#8217;ll get rid of them i won&#8217;t be myself anymore.  They were a considerable part of my life and somehow even helped me to carry on. Funnily, now that i&#8217;m fine i rarely want to paint. And it&#8217;s just in the head &#8211; like i don&#8217;t believe things should be  this way.<br />
(i sound like a psycho, do i? or a typical artist))<br />
 We don&#8217;t know what helped  him to maintain that imaginary balance before the infarction but there must&#8217;ve been something, some personal problems, anyway &#8211;  i&#8217;d rather believe it was so than that the screenwriters forgot  how to write.</p>
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		<title>By: Eyedunno</title>
		<link>http://www.politedissent.com/archives/2226/comment-page-3#comment-565774</link>
		<dc:creator>Eyedunno</dc:creator>
		<pubDate>Tue, 21 Jul 2009 01:39:47 +0000</pubDate>
		<guid isPermaLink="false">http://politedissent.com/?p=2226#comment-565774</guid>
		<description>&lt;i&gt;They’re all one-dimensional little twits. House is the only one who comes close to being realistic, but the writers just won’t let it be.&lt;/i&gt;
Amen.

Anyway, I &lt;i&gt;loved&lt;/i&gt; the mundane, &quot;you two are idiots&quot; solution to this one.

And I&#039;m a little curious about narcotics now.  I&#039;ve heard that heroin addicts can have their dependency managed with maintenance doses of heroin (or morphine, or whatever).  While I realize this kind of thing is presently impossible (or at least extremely difficult) in the United States (due to the DEA&#039;s ridiculous scheduling policies and the concomitant difficulty of obtaining controlled doses under medical supervision, not to mention the puritanical attitudes of Americans toward drug addiction in general, best exemplified on House by Tritter), I&#039;m now wondering if in fact heroin itself might be a better tool for helping heroin addicts to function than methadone is.  Scott mentioned the increased risk of respiratory depression from methadone (while also saying that this was overstated by the show), but then again, methadone lasts longer (if I remember correctly).

So what do you guys think?  Could heroin clinics be safer than methadone clinics?</description>
		<content:encoded><![CDATA[<p><i>They’re all one-dimensional little twits. House is the only one who comes close to being realistic, but the writers just won’t let it be.</i><br />
Amen.</p>
<p>Anyway, I <i>loved</i> the mundane, &#8220;you two are idiots&#8221; solution to this one.</p>
<p>And I&#8217;m a little curious about narcotics now.  I&#8217;ve heard that heroin addicts can have their dependency managed with maintenance doses of heroin (or morphine, or whatever).  While I realize this kind of thing is presently impossible (or at least extremely difficult) in the United States (due to the DEA&#8217;s ridiculous scheduling policies and the concomitant difficulty of obtaining controlled doses under medical supervision, not to mention the puritanical attitudes of Americans toward drug addiction in general, best exemplified on House by Tritter), I&#8217;m now wondering if in fact heroin itself might be a better tool for helping heroin addicts to function than methadone is.  Scott mentioned the increased risk of respiratory depression from methadone (while also saying that this was overstated by the show), but then again, methadone lasts longer (if I remember correctly).</p>
<p>So what do you guys think?  Could heroin clinics be safer than methadone clinics?</p>
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