House — Episode 24 (Season 5): “Both Sides Now” (SEASON FINALE)

A perfectly serviceable episode of House – for the middle of the season, anyway. As a season finale, it was a bit of a let down (until the last five minutes, that is).

Spoiler Alert!!

Scott is a 20 year-old who has undergone surgery that cut his corpus callosum (the part of the brain that allows the left and right sides of the brain to communicate) to treat a seizure disorder. The seizures have resolved since the surgery, but he has subsequently developed Alien Hand Syndrome, where he has no control at all over his left hand and it seems to have a mind of its own. He is at a restaurant on a date, complaining of bland food, when his left hand starts throwing rolls at an obnoxious diner at another table. A fight ensues, and before the melee even starts, we notice blood dripping from his eye.

Scott is admitted to House’s service for evaluation of his bloody tears and loss of his sense of taste. The initial differential diagnosis includes autoimmune disease, nasolacrimal tumor, infection, or the common cold. House has Taub and Thirteen search Scott’s apartment and they find mold growing on the ceiling in his bathroom. They decide this is the cause of his symptoms and start him on anti-fungal medication. About this time, Scott has a fight with his girlfriend, his left hand slapping her, and she storms out. He tries to follow her out but finds that he cannot walk. The differential now consists of dehydration or a meningioma (the most common tumor of the central nervous system) — only it’s a special meningioma that is allowing the two sides of the brain to communicate again. Instead of running an MRI or CT scan to look for the tumor, they run a test to see if there is communication between the left and right brain. The test is negative, but House notices that Scott is shivering. He also detects an ammonia scent to his breath and sees a caput medusae on physical exam, all signs of liver failure. House suspects the liver failure is due to sarcoidosis and has the team perform a liver biopsy. While performing the biopsy, Thirteen sees splinter hemorrhages (a sign of trauma or tiny blood clots) under Scott’s fingernails. He then takes a sudden turn for the worse, vomiting blood while his oxygen saturation and blood pressure drop.

The team now decides that Scott has a clotting issue, and start him on heparin (a blood thinner). An echocardiogram is normal, so the heart isn’t the source of the clots. They’ve also run tests for Factor V Leiden, Protein C, and Protein S (all things that can cause a clotting disorder), but they’re also negative. Thirteen now recalls his mention of always being sweaty and wonders if that might be a symptom of whatever disease he has. Cancer is thought to be the most likely, particularly lymphoma or pancreatic cancer. House strongly suspects the latter, even when an MRI of the pancreas is normal. He has Chase perform a new test where scorpion toxin and infrared dye is painted on the pancreas and will light up any cancer cells. There isn’t any sign of cancer, but once again Scott starts to develop a dangerously low blood pressure. House now realizes that the clotting problem is caused by his heart throwing off clots, but only when he slips into an arrhythmia, which he does under stress (like surgery or a biopsy), or every now and then. Sure enough, Chase checks a transesophageal echocardiogram and finds an abnormal rhythm and clots in the left atrial appendage. The heart throwing clots explains most of Scott’s symptoms, but what explains the heart condition? The new differential includes rhabdomyolysis (muscle disease), Graves disease (an autoimmune disease that causes too much thyroid hormone to be produced), and Cushing’s Syndrome (a condition where the body makes too much cortisol, a steroid). The Cushing’s seems the most likely, and a dexamethasone suppression test is ordered. About this time, Scott’s girlfriend returns and points out that his left hand only seemed to get “agitated” when Scott’s deodorant was involved. It turns out to be a special deodorant that Scott has to special order. Taub checks on it, and sure enough, one of the ingredients has been shown in one case to cause a heart condition and therefore this is decided to be the cause of Scott’s problem. End of case. Taub also notes ironically that the chemical has been implicated in seizure disorders, and maybe Scott had not needed the surgery in the first place.

House, 524

As usual, major complaints are in red, minor in blue, nit-picking in green:

Patient has neurological signs (loss of his sense of taste, inability to walk) and they even suspect a brain tumor, yet they never check a CT or MRI of the brain?

The liver failure, particularly the varices and caput medusae, developed way too quickly — or else they’ve been there for a while and the team did a piss-poor physical exam.

It caught my attention when the script was vague about propylene glycol causing “heart problems.” From what I can find, it can cause arrhythmia, particularly bradyarrhthmias (abnormally slow heart rates) and QRS abnormalities. I don’t see any connection between it and atrial fibrillation, the arrhythmia that would cause Scott’s symptoms (again, left unnamed in the script).

The patient is crashing in the OR and no one thinks to look at the cardiac monitors?

I was surprised how quickly the team accepted that propylene glycol caused his problems and just stopped there, other more likely causes left untested for.

While giving blood thinners to someone with a clotting disorder is a good idea, they might want to think twice about giving it to someone with bleeding esophageal varices (at least I assume he has them, that’s the only thing that fits and can explain the vomiting blood).

Chlorotoxin-based (scorpion venom) tumor paint has been used in animal models, but I’m not sure it’s been tested in humans yet. It seems like an extreme step to take though. One of the first things I was taught (and taught loudly) on my surgical rotation was “don’t mess with pancreas” — though the language was more colorful.

So a clot to the brain caused the lack of taste , but what caused the bloody tears?
And don’t tell me “subconjunctival hemorrhage,” that was an embarrassingly bad suggestion of Taub’s.

I like that the writers finally acknowledge that storylines are often built on single case reports (not that there’s necessarily anything wrong with that).

House, 523

The medical mystery was mediocre, and they never explained one of the opening symptoms. His underlying condition (Alien Hand Syndrome) was more interesting that the mystery: C. The final diagnosis fit the symptoms, or at least the main ones, it just seemed the team accepted that the deodorant caused it too easily. I give it a B. The medicine overall was superficial and rushed, but not horrible. I give it a weak B. The soap opera was the highlight of the show, particularly the end scenes with Cuddy and Wilson and earns the show an A in this regard (though shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?).

Last week’s House review
A list of all prior House reviews

265 Responses to “ House — Episode 24 (Season 5): “Both Sides Now” (SEASON FINALE) ”

  1. “though shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?”

    Probably, but at this point it’s hard to tell what’s real and what’s delusion.

  2. Truth be told, the drama surrounding House, his intellect, and his psyche is what keeps me watching the show. I think the medical mystery aspect of the show has gone a bit south since season 3, but the evolution of House’s character has been superbly done. I also really am amazed how each season has a distinct cinematographic style to it. Season 5 certainly had the most creepy vibe to it.

    I had a feeling the lipstick represented the vicodin bottle but I wasn’t sure…mainly just noticed the way he was handling it the same way he handled his scrip.

  3. Long-time reader, first-time poster.
    Thanks for the awesome reviews throughout the whole season.
    The episode was just terrific, and the last 5 minutes almost got me crying. Didn’t get just one thing about House. Is it schizophrenia?

  4. In the end i had no idea what actually happened, he never slept with her? She never helped him?

  5. I agree with P$. The medical aspect has not been the focus since at least season 3, but House himself is still fascinating.

    The ending of this episode was absolutely sinister. When Amber’s face appeared on the screen I wanted to hide under my chair.

  6. Cuddy and House slept together in college

  7. I agree with zY. When she popped in the side of the screen, I nearly crapped my pants. And then Kutner there? AUUUGGHHH.

  8. Wow! A VERY interesting ep at the end. I agree that most of this ep would not have held up w/o the ending which wasn’t really that much of a surprise….We’ve seen it coming and told ourselves “No…. not that, ANYTHING but that”.

    What DID surprise me was Amber’s return and then Kutner reinforcing that what he thought was real, really wasn’t.

    And House appeared SO happy at first….

    Now he has to face the consequences of choosing Vicodine (supposedly so he can continue to work pain free) or his physical AND mental health.

    “Everyone Lies” and it’s finally kicked House’s ass for him to find out that even he lies…..to himself, to Wilson and worst of all, to Cuddy (about his feelings for her).

    Next season hopefully will see more stronger then average episodes and it will be interesting to see if the writers can do a good job of extricating House from the mess he’s currently in….

    QUESTION: Is the facility House commits himself the3 same one that Wilson’s brother was/is in?

  9. It’s not schizophrenia – anyway, it wouldn’t appear for the first time in a House-aged guy (right?). It’s psychosis apparently induced by the vicodin. So he never slept with Cuddy, never even had her over to his place, as far as I can tell. For one thing, there was an explanation after all for how House overcame the withdrawal so fast: he didn’t.

    Man, if that psychiatric hospital didn’t look Dickensian. I wonder what the next season will be – will House’s problems be more or less solved in the first couple episodes/in the time (in the show’s storyline) between the seasons? (Honestly, that seems most likely, but would be pretty much a let down.) Or will House be solving problems of random crazies?

  10. Since that means the previous happenings in the prior episode did not occur, then my diagnosis of acetaminophen induced hepatic encephalitis still could be the culprit, with the new addition of delusions as well as hallucinations.

  11. @ Arlan: House was so loaded on Vicodin/potentially losing his mind, that he became completely immersed in his repressed emotional side: that is, that he knows he ought to quit using narcotics, and that he wants to hook up with Cuddy. This is in line with the medical mystery of the patient having disconnected brain hemispheres. Ultimately House is sent to a psychiatric hospital. Now whether or not this is a yet another hallucination will remain to be seen next season.

  12. Allison, I made a gif so you and everyone else can relive the creepiness.

    http://i27.photobucket.com/albums/c171/zygote7/house_s5finale.gif

    =D

  13. Blech. This one sucked even worse than last week. Total cop-out on the writing. For House OF ALL SHOWS to handle a major neurological symptom like realistic, consistent audiovisual hallucinations this poorly is just pathetic. It’s about as believable as the old “general amnesia” device. I know, why don’t we have House relive a couple past lives while we’re at it? And surely there’s room for a few undercover secret agents to come through the clinic next season? Maybe Cameron’s ex-husband can come back from the dead and turn her and Chase’s marriage on its head? It’s full steam ahead for next season’s hottest drama!

    Garbage plotting, garbage characterization … just pathetic.

  14. I actually quite enjoyed this episode, especially – like Scott – the last five minutes or so. The fact that House had hallucinated many of the events of the previous episode was a definite curve-ball that was enjoyable in its own right (not to see House being committed, just to realize that there was yet another twist to the story.)

    I’m curious as to what will happen next season. I agree with the commenters above that said that it is the personality and character of House that have really risen up to help carry the show. The journey through his eyes that the story has taken us on this season has really been quite interesting, and being a person who has bipolar disorder herself (and just being a person interested in cognitive science and psychiatry, it is neat to watch a show that depicts a walk down the psychiatric labyrinth of a person’s mind in such a vivid way.

    I appreciate the show, and I appreciate the attention to and greater understanding of many aspects of the medical world (even though there is still work to be done with this – I assent. :)) Many thanks, Dr. Scott, for taking the time and effort to give us insights from a doctor’s point of view. It’s greatly appreciated.

  15. Oops, a typo in my previous post – I meant to say that I “appreciate the attention to and greater understanding of many aspects of the medical world that the show has brought about among many viewers…”

    Yay for House! :)

  16. maybe House is having a hallucination of a hallucination
    is that possible?
    cant wait till next season, 3 and a half more months

  17. My big question is how did his right hemisphere know that the deodorant was causing the symptoms?

  18. Was disappointed that an hour was not enough to satisfy for a finale. I figured the entire thing was a hallucination once Cutty mentioned in the beginning that they should be strictly professional and that “we never had a personal relationship.” However, I never got what the writers were trying to get at by having House flash back to an earlier season episode where House insulted Cutty. If memory serves me correct, that’s also the episode where they first kissed. Or did they insert that to show us that incident was a hallucination too?

    If this indeed is a case of hallucinations, I wonder how many other incidents in previous episodes were all in his head?

    Finally, Amber represented his subconscious, but why was Kutner there too? To represent his guilt over his death?

    Wish it was a two parter!!! Arghhhh!!!

  19. This is the best series ever…Watched it like 3-4 times each episode….

  20. “though shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?”

    Cuddy might have thought House was referring to their one-night stand so many years ago.

    @Garrett: That scene was inserted because House thought he mentioned to Cuddy that he was hallucinating (he really did not), which prompted the kissing, the detoxing, and the sex to “happen”. They only flashbacked the previous ep.

  21. House was taking oxycodone since the night when he hallucinated Cuddy at his apartment. We were shown House fondling/hallucinating that lipstick all day but it was shown in the last few minutes to be a bottle of oxycodone.

    Calling back to a previous episode when he was on it and had no pain… *that’s* why he felt like he had detoxed and also why he wasn’t feeling pain this whole episode.

  22. Hold on,
    Didnt his script bottle say Oxycodone?
    When/why did he start taking that?

    Or am I just missing sometihng.

  23. Woah , i liked the soap in this episode. Season 5 has been much more “happening” in terms of the drama than other seasons. Really excited to know what is gonna happen in season 6.

  24. Oops, disregard that.

    Said HYDROcondone aka Vicodin.

  25. The “revelation” scene and the finale went a long way to making up for what I thought was a rather lackluster episode. I found myself reminded of a certain movie in which a certain character says, “The dead see what they want to see.” Not that I’m implying that Dr. Gregory House is dead – but his realization of what actually happened, down to the “lipstick” he thought he carrying in his pocket, tingled with a similar horror.

    It’s also kind of funny to look back at people’s objections to last week’s episode — You can’t wean yourself off Vicodin in one night! No way Cuddy would want to kiss him after all that! — and realize none of it was real.

    Props to those who foresaw that it was all a hallucination. And good to see Kal Penn one more time.

  26. You can tell that the patient story this week was rushed badly to leave enough time at the end. Makes me wonder if they should have just dropped the patient story this time and just done a “character” episode instead.

    I think the point here is that House’s hallucinations became so vivid that he can no longer tell that he’s hallucinating. He is headed down a very dark road.

    Tell me again why it was decided to kill Amber off? She’s contributed more to this season as a dead character than some of the living ones!

  27. Oops, I was in error up there. House was taking methadone when he was feeling no pain back in “The Softer Side”. But I am 99% sure he was taking oxycodone this episode. I’ve capped slo-mos of the bottle dropping and run them through a sharpen filter in Photoshop. It’s oxycodone.

  28. Blerg! The mind sees what it wants to see.

    The Fox.com recap confirms it’s Vicodin House dropped on the floor of Cuddy’s office.

  29. I just wanna ask, can’t they just TIE the left limb while performing tests? I mean, that alien limb caused a lot of trouble for the team, and they just let it do those things.

    Another thing, before watching this episode, I was suspecting (more of having a WILD GUESS) that House really had another hallucination, and the whole Cuddy thing was a hallucination, turns out I was right. But I was still shocked when Amber and Kutner appeared. Anyway, the show really fooled us this time, and even though I was HOPING that House would go nuts about Kutner’s death, seeing it happen made me feel really sad. Can’t wait for next season…

  30. i can’t wait to see the next season. this is my favorite tv series!
    i can’t comment on the medical aspects of this series. i’m not in the medical world. all i can do is get affected and be concerned about my health…but i love the show because of gregory house,the wilson and house friendship and the house and cuddy love-sex life. i also like foreman because of his angst. if not because of him, i would really find house’s team boring. i prefer the previous ones. and please stop the cameron thingy being fixated to his ex-husband’s memory.please!

  31. Well, to be honest it was disappointing for me to see the outcome of this storyline after Kutner’s death. If House is to be the one to solve mysteries, then why didn’t he concentrate on finding out who killed Kutner? Saying that Kutner just killed himself with no reason whatsoever is just dumb… I hope they will find out who really killed Kutner, maybe its House?

  32. The bottle was pretty jumbled, all i could see was (jumble)CODONE. I’m assuming it’s hydro-? All prescription labels will say HYDROCODONE/APAP if it’s generic because just plain hydro isn’t available; it has to be in combination which is why it’s schedule III. Oxycodone is available by itself though. The writers aren’t that great at making the drug therapy part of the show authentic (remember that ambien bottle, lol).

    This episode was sweet. I need to watch it again (and the ep before) now that we know what’s really going on. Bravo to House for committing himself, that’s a really bid deal. Back in mid April when CTB first reappeared, I thought it was Wernicke-Korsakoff syndrome (encephalopathy secondary to acetaminophen abuse which progressed to Korsakoff’s psychosis which presents with symptoms such as anterograde/retrograde amnesia, CONFABULATION, that is, invented memories which are then taken as true due to gaps in memory sometimes associated with blackouts, meager content in conversation, lack of insight, or apathy). Okay either that or House is just plain old schizo, in that case just get him some risperidone and he’ll be in good shape for the next season!

    -Pharmacy Student

  33. Hah, the detox in on day thing seemed too unreal to be real. And it was luckily. POTW seemed fine for most of the time it seemed except for his cool Alien Hand Syndrom. (And of course his liver failure, his blood pressure dropping and puking blood). Which makes me wonder if this episode would be better only opera and less medicine. Just for once.

    Also House killing Kutner? Seems unlikely since his symptoms are now just getting worse. From having hallucinations to a delusion.

    So that House had a delusion and killed Kutner seems very unlikely. Would be cool though but also creepy and maybe too melodramatic.

    Schizophrenia seems most likely now I think, that’s why he sent to a psychiatric hospital. But for the love of God or House I don’t hope that he will stay there for a couple of episodes. But at least 4 episodes or else it seems that either the psychiatric hospital has magic powers or schizophrenia or the other thing causing his hallucinations and delusion are just nothing.

  34. How is a schizophrenic doctor going to practice, anyway? I was under the impression that if House were committed he would lose his medical license.

  35. I would have thought that was discrimination.

  36. How is a schizophrenic doctor going to practice, anyway? I was under the impression that if House were committed he would lose his medical license.

    ^^^
    This was my first thought as well. If I recall correctly, this is what had been keeping house from comitting himseld once he realized he was having hallucinations to begin with. Can’t really have House MD the TV show if the main charactor looses his medical license. Then again…. I suppose I can think of dozens of times in the pas that House should have had his license revoked so… who knows?

  37. Another medical question: when they were doing the test showing visual stimuli to the different eyes, they mentioned that what was shown to one eye would be communicated to the opposite hemisphere of the brain. I thought that I remember from my 1 anat/physio class that the eyes are an anomaly to that, and they connect “straight back” to the *same* hemisphere. Or am I hallucinating that memory? ;) I could accept if the writers did it on purpose to keep consistency and not have to explain that it’s different, and why, I just want to know if I remember that right.

  38. At GG from VA

    Lose not loose

    I don’t get it too, is House schizo or just hallucinating from Vicodin addiction?

  39. Zypchick,

    The visual fields get confusing: some of the nerves from the eyes cross in the optic chiasm, some don’t. Here’s a diagram, albeit a somewhat confusing one. In general, the medial (inner) aspect stays on the same side, while the lateral (outer) aspect crosses over. If memory serves, the screens were set pretty far to the side, so the lateral vision would be involved.

  40. @Andrew: I’m not a psychiatrist, but… my understanding is that many suicides do occurr without anyone knowing anything is wrong beforehand or being able to figure out why afterwards. It’s scary, but true, and exactly the sort of uncontrollable, tragic irrationality that House is desperately ill-equipped to deal with.

  41. I was interested to see that everybody who claimed last week that the soap made no sense (Cuddy abandoning/being able to arrange an instant overnight sitter for her baby, overnight cold turkey, even kissing someone who’d been throwing up all night) was proved right.

    Did everybody misunderstood what Cameron wanted from Chase in the previous episode? It seemed as if she was asking him for a vial of sperm to keep as her own, along with her first husband’s (a “liquid prenup”). But in this episode it is clear that he wants her to destroy the first husband’s sperm. This situation was perhaps not well thought out by the writers and certainly not well presented.

    It was also noticeable that House had little to do with the solution to the main patient’s problem. The patient’s girlfriend gave the team the clue to the solution. In the meantime, House had diagnosed the wrong patient with pancreatic cancer, dismissing the cancerous patient as suffering from a minor complaint. It seems that it is House’s realization that he diagnosed the wrong patient which makes him desperate enough to try to get a real confrontation with Cuddy.

    A medical question (from one who does not watch other medical TV series and has had exactly one operation): do doctors really choose the middle of an operation to condole with each other on breakups (Foreman and Chase) or makeup after breaking up (Cameron and Chase)? No wonder “no one thinks to look at the cardiac monitors” as Scott notes.

  42. For me the medical mystery this week and last week is House. The medical cases of the ballerina and the roll tosser serve to demonstrate to me the confusion in House’s mind. In both of these cases he makes suggestions that House himself later realizes are not based on true perceptions. He sees guilt in the ballerina’s boyfriend and he sees problems with a pancreas and transfers the diagnosis to the roll tosser. There is no white board style differential diagnoses performed in these cases. The differential diagnosis was done by House in the last episode on the case of House and he has narrowed it down to his drug addiction or schizophrenia.

    I could definitely see that either drug addiction or schizophrenia, if left untreated, could disqualify a physician from practicing. Is there any standard for doctors who have undergone treatment? And, presumably, there is a sliding scale of severity for both problems, although House seems to be at a pretty severe stage to me.

    Was House’s self-done differential diagnosis correct? What would happen next in his case? Detox and then see if he is still seeing dead people? Or therapy and detox at the same time?

    I thought the Cameron and Chase scenes were well done and the brief, very normal wedding was a perfect contrast to the dark wanderings of House’s brain.

  43. Hey, you missed the POTW!

    It’s was *Carl Reiner.* The whole DDx of the obvious patient of the week is messed up by House, because, mentally, he’s treating the old guy that he knows has pancreatic cancer, not the kid. This is why they don’t really resolve the issue with the kid — he’s not the patient that we’re focusing on.

    That realization — that he was really treating Reiner — is the real start of the downfall into reality. The ending is when he pulls the “lipstick” out in front of the one person he knows isn’t going to believe that it’s Cuddy’s lipstick. At that point, he see Amber again, who calls him on his bullshit, then he see Kutner, who condemns him. To me, however, the real payoff is when Cuddy and House walk into Wilson’s office — no words are said, the faces say it all.

    I knew something wasn’t right at the start — the camera work was shaky enough to make me nauseous, the lipstick on House’s face disappears, and Cuddy’s actions didn’t make sense.

    So, when you go scoring the contest, remember, you had two patients — plus House.

  44. I’m pretty sure it’s not schizophrenia guys…it’s been said above, a complication of either acetaminophen or Vicodin abuse.

    Also I can’t believe people are so confused about the big awful plot twist in this episode. The _whole_ detox was a hallucination/fantasy, not just the Cuddy helping/sex bit (god damn it). He never even asked Cuddy to help him, and he definitely never detoxed from Vicodin. He maaaaay have insulted her baby in her office (if he even went to her office that night) but that’s about it.
    Which is really frustrating…seriously, it was all a dream…?

    Rewatching this episode is horrible. Everything that made me ecstatic in the beginning is now horribly, somberly crazy-coloured.

  45. Two questions about the episode:

    1) did he go to detox or for inpatient psychiatric treatment at the end?

    2) I am not a cinematography expert — can’t even spell it — but I noticed a couple times in the episode that the cameras were kind of shaky and there were some weird camera angles, like it was a mockumentary type thing. I wonder if that is a clue to when it is a hallucination?? Did anyone else notice it? This was way before the twist at the end, which I thought was really cool and had me yelling, “no way?!?!?!?” at the TV!

  46. This was a powerful episode although it left me with a bitter taste in my mouth. The fact that I was happy about something that never actually happened was…well unpleasant. However it was so “House” so in the stile of the show I couldn’t help but applaud it. The replays of him realizing his hallucination were creepy to the point of me shivering. Amber and Kutner were the cherry on the top of the cake. I’m too shaken to talk medicine so I’ll just leave it there – I’ll re watch the episode again and again it is without a doubt among the best in the whole run of the series.

  47. Long time, first time.

    After this episode, I’m really looking forward to the start of the next season. We may infer, for example, that while House is away, Cuddy will put Foreman in charge of the department. Since it is assumed that time passes in TV Land, Foreman will have spent 3.5 months running the show. When this happened between season 2 and 3(while House was recovering from being shot), it was probably understood that Foreman was “keeping the seat warm” or somesuch. With this situation, however, there’s no way for any of the characters to know when(if) House is coming back(of course, we viewers can expect a bombastic return, I’m sure).

    Because of this, I sincerely hope that we get to see a couple of cases where Foreman is truly in charge, having settled into his role as a department head, with House getting sane/sober as a completely separate B-plot. Then, when he returns, the power struggle begins in earnest.

  48. Was the Chase/Cameron wedding real or delusional?

    House already tried to kill Chase at the bachelor party and who gets married to “As Tears Go By” ?

  49. Physician diagnose thyself!

    I think that will be the theme of next season’s early episodes. House will find the underlying cause of his condition, and true to his world view, it will be something physical rather than psychological.

  50. i don’t know whether it was already answered, but the question of whether they will include “psychical recovery” of House in the next season should be at least to some extent answered by this:

    http://www.nj.com/news/index.ssf/2009/04/tv_show_house_to_film_at_greys.html

    Really looking forward for S06!

  51. Head Amber is back! I thought she would have been more malicious during his “detox” but now I can’t wait to see her really cut loose next season.

  52. @ bex

    He went to a psychiatric facility because of the vicodin abuse(or as it was written on the bottle pill/lipstick this episode “Oxycodone”).

    Drug-induced psychosis. And I read that the hallucinations and delusions can present even if the person has been clean for some time.

    And when House started walking towards the facility the way they filmed him totally ruined the moment for me. I kept thinking of scenes from “final destination/scary movie” where the person gets hit by a bus !

    http://i41.tinypic.com/2dsqyj5.jpg

  53. @ bex re: cinematography: I had noticed that, too. For the past several episodes (since Kutner’s suicide, amybe?), the camera seems to have been doing one of two things when something isn’t quite right:

    - In the early hallucination episodes, they seem to have been applying a blown out look to the hallucination scenes, ie, everything gets sort of whiter and softer in focus.

    - In last night’s opening scene, for instance, they’ve been using a cooling filter, handheld camera, and shallow depth of field (e.g., House’s eyes would be in focus but his ears wouldn’t be)

    I’d assume there’s some sort of logic at work, but I am under caffeinated right now. :)

  54. Remember the ending to St. Elsewhere? Maybe this whole season was a hallucination. When Obama fires “Kutner” he’ll be back as if nothing ever happened.

  55. I think that Carl Reiner deserves at least an honorable mention. His change in demeanor as he goes from thinking he has heart burn to pancreatic cancer was a subtle but noteworthy performance. It also foreshadowed House’s own change in demeanor as he goes from thinking he was cured off drugs and pain to realizing he’s psychotic.

  56. The reason Cuddy wasnt mad about lying is part of the mystery of House when he was in Med school, think back to the earlier eppisodes (cant remember which) when he makes reference to one night when he gave her everything she wanted. This is supposed to be a hint at what may have happened between them in past wish would be why she never accused him of lying.

  57. Oh, and I’d like to add that the emergence of Wilson’s brother now makes more sense. When I first read about House filming in Greystone last month (I live in Jersey and it was in the local papers), I thought that it would involve Wilson’s brother. If not for that, House’s committal would not have been a surprise. The producers must have known they needed to give fans a reason for filming there.

  58. @joseph — Chase/Cameron wedding — something that didn’t match up was that Taub had asked if the wedding was really “black tie” but what they showed at the end was definitely not black tie…maybe it is another hallucination.

  59. This was a crappy episode until the last 5 minutes which totally made up for it actually. I had to watch that part two times.

  60. @merp

    I seem to recall the blown out lighting happening in the episode where House was taking excessive amounts of caffeine to stay awake and continue hallucinating. A similar effect happened to me when I’d been up for 36 hours studying while popping caffeine pills — everything looked very, very bright (probably had something to do with my eyes being dilated, but don’t quote me on that). Might have been an attempt to show how the world looked to House.

  61. Carl Reiner made this episode for me. And Jennifer Morrison had some great acting. The second scene between Cameron and Chase (not the OR scene) could have been really cheesy, but she sold it perfectly.

    I had to watch it three times, and there’s only one thing I’m still unsure of.

    Was the scene where Cuddy pulls House away “to talk” real? House makes the comment: “Isn’t that like locking the barn door after the horse has put is face between your breasts for an hour and a half?”

    Cuddy doesn’t seem confused at all by the statement. Because it was the two of them alone, it feasibly could have been another invented memory in place of what they really talked about. Hopefully they’ll do a commentary on this episode for the DVD, and we’ll get a full explanation.

    As has been mentioned, in the scene where Cuddy fires House, she’s referring to the hookup 20 years ago.

    Also, if Vicodin was responsible for the Amber hallucinations, it could be responsible for the delusions. Maybe that doesn’t make perfect medical sense, but it’s good enough to fool someone like me. Getting him off Vicodin (or replacing it with another drug) could be how they get out of this next season. As much as the House writers are willing to stretch the bounds of medical reality, even they couldn’t think that a diagnosed schizophrenic could be practicing medicine.

    We’ve been teased with the “House quits Vicodin” plot a thousand times, but this is the first time I could really see it sticking.

  62. Who the hell is Carl Reiner?

  63. You know, if they wanted to, they could blame the bus crash from last season as being the cause of House’s hallucinations. They could then claim that Amber never really died. House imagined it. (They could still say Kutner committed suicide or simply left the hospital for any other reason they chose.) Basically, they can reset the series back to the end of last season if they chose. As it is, they could always say the motorbike accident in “Locked In” is what caused the head injury bringing about House’s delusions. If they don’t blame the Vicodin.

  64. “Who the hell is Carl Reiner?”

    Alan Brady on “The Dick Van Dyke Show”, producer of that series, writer for “Your Show of Shows” and father of Rob “Meathead” Reiner.

  65. Judy,

    When Chase said, “You want a prenup… in liquid form?” he was referring to the “liquid” of her dead husband. The “prenup” is allowing her to keep it in case she and Chase get divorced before they have kids. Then Cameron still has the old “liquid” to use.

    I initially thought that the phrase meant that she wanted Chase to give his own “liquid”, but they made the meaning pretty clear in this episode.

  66. “(though shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?).”

    Scott,

    House and Cuddy have slept together at least once. This was revealed in S4, Top Secret. House said one night he gave Cuddy everything she wanted and she returned the favor with a job. I’m paraphrasing but that’s the gist of it.

  67. Opps!! Correction TOP SECRET was in Season 3

  68. Hell, you get another person of your nationality to comment on the blog you’re frequently reading and he MUST show how ignorant and painfully juvenile he is.

    As for the usual thing: long time, first time, you know the drill. I must say I’m quite impressed with the way they handled crappy shippers’ fanservice from the previous episode. Then again, I’m afraid they might jump the shark with the whole madHouse arc.

  69. Hey guys, I’m pretty sure that if a doctor is a diagnosed schizophrenic AND stabilized on medicines + a psychosocial rehabilitation program, then they could prolly practice as a doctor in some capacity (some non-autonomous role). Buuut, co-occurring disorders (like substance abuse!) limits symptom and functional improvement and increases the risk of relapse — so House would probably be screwed. HOWEVER, for House to be schizo this is really late onset (usually manifests in males in early 20s & females in late 20s). It’s something else… prolly related to his beloved Vicodin, because everything on House revolves around it.

    If they pull some brain tumor crap and everything is cured with some surgery (like Thirteen’s blindness), i’ll be pissed, lol!

    -Pharmacy Student

  70. Keep in mind that the last few eps of EVERY season of House have been surreal, trying to capture the fantastic ‘Three Stories’ ep again.

    A shift toward mental illness type subjects might be interesting. Hugh Laurie has talked about his own depression, and his longtime comedy partner Stephen Fry has been very public about having
    bipolar disorder.

  71. Man, I hated that ending. H-aaaaaa-teeeeddddd. I wish, wish, wish, for once, the writers of this show would accept the consequences of a plotline without throwing it all away an episode later.

  72. Hello!

    Never wrote here before, loyal reader though…

    Here is what I was thinking after seeing last ep.:

    What about in season six, instead of princeton plainsboro we”ll see this psychiatric hospital and House unofficially working on psychiatric cases?
    I think it’s quite possible, because on the one hand at the end of season 5 IMHO it’s getting little SSDD, same disorders, different ways of finding them out. On the other hand I don’t recall any cases involving any psychiatric disorders or mental illnesses, which actually might be intersting, people like this stuff :) And the last thing- starting season 6 at princeton plainsboro after putting him in the mental instituttion (if it wasn’t his dillusion of course) is so-not-house style :))

    P.S. excuse my english

  73. @Erik That realization — that he was really treating Reiner — is the real start of the downfall into reality.
    ______________________

    What was startling about this scene is how gently House treated Reiner — “Take him to radiology and stay with him” even while the panic is starting to take hold. And Reiner’s bewilderment mirrors House’s when he realizes he has made everything up. It was beautifully handled, I thought. I couldn’t believe how sad those last moments were, especially since most of the episode had me laughing so hard. Well, I feel bruised and beaten.

    Thanks for this blog. I read it every week.

  74. House was not on vicodin. He was on acetaminophen–which makes me think his problem is caused by the opiate itself.

    LOVED THE ENDING

  75. Can’t really have House MD the TV show if the main character loses his medical license.
    It didn’t stop Dr. Buffer (although he turned himself in) or Ridiculously Old Fraud (although he got fired).

    I’m also wondering about the reality of the wedding. Would Wilson and House not at least put in a quick appearance before heading to the Psych Hospital? (BTW, there was a good-looking woman walking into the hospital along with House and the other doctors/attendants.)

    Maybe this whole season was a hallucination. When Obama fires “Kutner”, he’ll be back as if nothing ever happened.
    I believe the phrase, ironically enough, is ‘being thrown under the bus.’

  76. psychiatric hospital and House unofficially working on psychiatric cases?
    Another commenter suggested the same thing, above, Nina. And that would be interesting. Who knows–maybe the Greystone staff will find House so useful, that they’ll try to keep him committed even after he’s cured? ;^)

  77. Did anyone notice that when Wilson was driving House to the psych hospital, there was a brief scene that was IDENTICAL to the scene in episode 4, “Birthmarks”, when Wilson was driving House to his father’s funeral? (House looking out the car window and then at Wilson quizzically?

    Also, to muddy the waters, I had a thought, probably VERY far-fetched, that perhaps the whole episode was an hallucination, the patient symbolizing House’s ’split’ with reality? Maybe that’s why the medicine was sloppy and not really ever having a solid conclusion? I mean, have you EVER seen Taub act like that, the way he was badgering Chase, with whom he barely had any kind of relationship at all? It seemed that all the characters were a bit ‘off’.

    And finally, I enjoyed the symmetry of the pilot and this episode both featuring Rolling Stones’ songs, and BOTH having to do with some sort of House/Cuddy confrontation!

  78. My Quibble Of The Week, since I am not a doctor, is with how they performed the visual fields test. They didn’t even bother with SINGLE-blind! Yes, I know the audience needs it explained, but IRL human suggestivity means that telling them what the results should be = bad idea.

    RE: Kutner — Kal Penn has already confirmed that it was a suicide. No foul play.

  79. Excellent chapter!!!!

    The acting was great. Cameron’s reaction when Chase told her about her problem was lovable! House’s expression when entered Wilson’s office with Cuddy was priceless! The “no words” reclusion of House in the mental institution was great. Amber OMG!!!! The way she appeared; and the moment!!! The timing was perfect!!!! Just like the “enjoy yourself” part in the previous episode. I didn’t care about the patients at all, i was too busy trying to figure out what was going on with House and Cuddy.

    I HATE to wait so much for next Season, and i hope the DVD comes out asap so i can grab it and continue my collection of this great series.

    I would like to sincerely thank Scott for writing and maintaining this site. Cya guys next season.

    Heishiro

  80. Joseph ~ I thought the same thing – weird that Cameron & Chase would be married to As Tears Go By. In reflecting on
    it, I think the song is meant to speak to House’s mental state: House is the one who : ” Smiling faces I can see but not for me”. Moreover, the show has a history of using Rolling Stones theme songs for House. Compare with season finale where House throws vicodin bottle in the air to the tune of I Can’t Get No Satisfaction, which was played as well for opening song of Season I.

    Can someone who saw the show more than once cite the line when House realizes that the Carl Reiner character may have pancreatic cancer? House says something like, ‘my subconscious was trying to tell me that’. He had taken to ignoring that subconscious voice, personified by Amber, because it was scaring him, especially after she/he endangered Chase’s life. It seems in his efforts to gain control of himself and circumstances that
    cannot be controlled – Amber’s death, Kutner’s suicide -
    that House is in such conflict with himself that he has lost
    his gift for diagnosis, long the key to his sense of himself, as well as his tenuous hold on sanity. No doubt that House had a serious personality disorder long before surgery and vicodin came into his life. All three characters: House, Wilson, Cuddy, played that realization of the
    loss of self scene beautifully at the end. Great TV.

  81. Two more notes:

    1. Taub harassing Chase in the cafeteria was hilarious.
    2. I haven’t seen the redhead girlfriend in anything since “Strangers With Candy” almost a decade ago. That was a pleasant nostalgia.

  82. Well it seems Tritter (remember the mean cop from season 3?) was right all along …

  83. Yay for me! I’m not that flexible but I’m trying my damnedest to pat myself on the back. I haven’t gotten a diagnosis in two years, yet I’m lucky enough to call the hallucinated detox/sex romp. House reaching the realization while at the hospital was a surprise (I expected him to still be sitting on his bathroom floor or already in the mental hospital), but I think it was a pretty cool way to allow everything to unfold as if we were in House’s head.

    As for the POTW, I thought the Alien Hand was awesome and I, too, am really upset that wasn’t discussed/investigated more. Glad this season’s over so I can focus on studying for Step 1, but I’m already looking forward to Season 6.

  84. Also the bottle House thought was lipstick, was it Oxycodone? If so how did he get it?

  85. Well it seems Tritter

    Who?

  86. About Cuddy and House, please remember that 1st season episode (I think it’s “Mob Rules”) when Vogler infers that Cuddy has slept with House sometime in the past. Cuddy just says the assumption is rude and/or inappropriate, but never says she never did sleep with House. Just food for thought…

  87. Oxycodone, vicodin, who cares? And I really can’t believe that some of you actually went frame by frame to read what the label said. And photoshop!! Seriously, get a life.

  88. Tritter was a police detective who was obsessed with convicting House on drug charges after House humiliated Tritter as a clinic duty patient, giving an insincere ‘apology’.
    http://en.wikipedia.org/wiki/Michael_Tritter

  89. As an earlier poster said, how did Right Brain know the deodorant was the problem? I was expecting them to mention some sort of sore or something in his underarm. But then, the right brain is better at pattern matching, so maybe it does make sense that it determined a connection between application of deodorant and Bad Stuff.

    As for what actually happened — my wife noticed that Wilson looked especially tired in some scenes. I think in those scenes, that wasn’t Wilson; that was a House hallucination (representing an aspect of himself). Several of the scenes with Cuddy probably never happened. The first one, where she’s pissed about his remark, he misunderstands. The announcement to the lobby (and subsequent firing) never happened.

    The bottle seemed to say just “Hydrocodone” (not Hydrocodone/APAP), but we couldn’t see the whole bottle and they’ve done the bottles wrong before.

  90. Didn’t Grey’s Anatomy do the seeing-dead-spouseslovers/thing? And wasn’t the cause a tumour pressing on the temporal lobe? This jumped out at me when House had his list of possible causes on last weeks show; there was no cancer on it. Maybe his are from the drugs or late-onset schizophrenia (surely he could have had minor episodes that would have been dismissed due to his odd and perplexing behaviour that is ‘normal’ for house, and he does have a strong tendancy to isolate. No one may have seen it….) or maybe not. I don’t understand how Wilson, as a cancer doc could not have considered it. Maybe that is what season 6 will resolve, because I don’t know how they are going to get House out of the looney bin.

  91. A few random comments/questions:

    Since we know that the last part of the previous episode was House’s hallucination, can we be sure that everything we saw in this episode actually happened? Obviously, the lipstick was not real. But was the patient real?

    As far as what medication House is taking, when he dropped the bottle, it definitely said OCODONE. The part previous to that was unreadable, but I think that eliminates the possibility of oxycodone. I was watching in high definition on a large screen, so there is no doubt that the character before the CODONE was an O.

    Knowing that House abuses his painkillers, isn’t it malpractice for Wilson/Cuddy/whoever to prescribe Hydrocodone, with the possibility of liver damage from the acetaminophen? Considering that the Hydrocodone does not seem to be sufficient to relieve House’s pain, why wouldn’t they try oxycodone or oral morphine, rather than the jump to methadone, as they did in one episode.

    I am just a layman, but it seems to me that the show dramatically overstates the dangers of opiates/opioids when used for pain relief. In particular, there seems to be very little evidence of opiate-related psychosis. Dr. Lawrence Kolb, Assistant Surgeon General of the United States Public Health Service, said in 1962, “Chronic psychoses as a result of the excessive use of opiates are virtually non-existent.”

    See:

  92. Did anyone else feel incredibly cheated by House’s sudden onset of an unexplained, cartoonish, ambiguous, and overall cheesy insanity?

    The writers definitely did not earn this turn of his character. Yes, they were building up to it. But they skipped way to the end. Why is he crazy? How is he crazy? Why did that come up all of the sudden?

    And “House can’t tell what’s delusion and what’s reality” is a euphemism for “We’re too sloppy to have consistent narrative, so we’ll explain plotholes with a metaplot gimmick, a “Gotcha!” moment, and a wink-and-nudge at the audience” or in fewer words “We’re just covering our asses.”

  93. I was disappointed with this episode until the end. I’ve been disappoiinted with this entire season. The medical mysteries have been hit and miss since season 3, and as much as I like the drama behind House, I originally watched for the medical mysteries and jerky doctor that solved them.

    The end seems to fit with House as a character. Most, if not all, season finales have been from inside of House’s mind. I hope next season is good, and can return to some of its original form. I’m tired of being disappointed in House.

  94. I’m still looking for an answer:

    Is the facility House commits himself to the same one that Wilson’s brother was/is in?

    If it is, this would open a whole new direction for thew writers to go in next season.

  95. I suppose much of us will be looking for the answer to “What exactly is wrong with House?” the whole summer?…I still must stick to my guns though – it is psychological it has something to do with Cuddy, Amber and Kutner and it is aggravated (not caused!) by Vicodin abuse. Just had a funny though (and an idea – may be the writers will pick up on me?) about season 6. House will need psych counseling along with the detox right? So why not bring Myra Sorvino back to do the couseling? She had House “all figured out” way back in season 3 (the episode with the best ratings ever “Frozen”). Then sinse she expressed interest in returning to the show as House’s love interest may be a triangle can be formed between House her and Cuddy (who I think was hiding her pain by not walking House to the mental hospital instead of going to the wedding). House getting cured by her/by love is interesting storry line and I think he will not be magically cure – may be we’ll still see more of Amber (and Kutner?) from time to time just as a reminder of what he’s been through and what still lurks in the darkness for him. Anyway speculations will go on and on the one thing I’m actually happy about (and is 100% sure) is that Hugh Laurie is contracted for another season so we’ll see more of him. And HE is the one man show here – he’ll rise from the ashes stronger then ever and keep on abusing people while saving their lives! :-)
    P.S. Unless it was a hallucination in the previous episode Wilson and House searched his head for tumors (and his blood for tumor markers) So no tumor and stop making comparisons to Grey’s anatomy guys – they jumped the shark way way long ago and the waning ratings are confirming it – the once proud star show of ABC is circling the drain.

  96. How realistically was Alien Hand Syndrome portrayed? I thought I would come here to find at least a few complaints about it being exaggerated, but neither Scott nor any of the other posters have complained. I didn’t know AHS even existed until I saw this episode.

    I agree this episode wasn’t anything special, but the end more than makes up for it. House is really starting to break. I don’t think we’ve ever seen him as pants-crappingly scared as he was at the end of this episode.

  97. Looking at the psychiatric staff that escorted House in, they are basically the same racial and sexual makeup of his last two teams: one white woman, a black (colored) man, and a white (light-skinned) man. Either disregarding Foreman for the majority of the second team, or disregarding Kutner for being dead, he a nearly identical group of people walking him into the center. Maybe they’re all just cameos and will have nothing to do with the next season. But knowing how much the writers try to plan stuff out for the long term, they may be the next “team” for the show.

  98. I liked the finale very much…When I thought that finally House was gonna have a “happy ending” with Cuddy and for once become “normal” (in love, pain free, no addictions, planning to move in with Cuddy), the shows goes head over hills and tells us that everything was just hallucination..That was super!

    And Amber and Kutner, haunting him…very nice!

    The “right”brain of House had been telling him that he was “substituting Vicodine for Cuddy”(while talking to Wilson), and when he had his wake up…Man, I felt PITY and so SORRY for him… Let’s see what the next season is gonna bring us, I hope a better House, the writers have to put him out of his misery! Poor guy!

    I always watch the episodes online, cos I live in the Netherlands and here they are still busy with the 4th season, it’s such a pity cos most of the times the videos aren’t HD… I can’t wait to watch the 6th season!

  99. It did seem to me that the patient’s previous doctors had been a tad precipitate in performing brain surgery on him – what, he was never, with all of the testing and so forth that would have to lead up to that, without his deodorant?

  100. gosh, everyone seemed really OOC this episode. cuddy in a good way, she finally got some back and told house where to go. wilson though, encouraging house to make her mad? so not to type. and taub following chase was funny, but do they even know each other? strange. im thinking the whole season has been one massive hallucination. though some of these scenes were incredible. cuddy shouting at house down the hallway and then that laughter? brilliant. and house smiling thinking she was going to say yes. heartbreaking. and those end scenes where he realises the hallucinations.. i honestly got the creeps. the lipstick was such a nice touch. this show will always be 100x better than anything else on tv, even if it does suck in some areas.

  101. Guys,
    There is no way House could have schizophrenia….he is waaaay beyond the two main age ranges of onset. It is clearly drug-induced psychosis…

  102. Hey Scott,

    Love the reviews….been reading them since season 2.

    Going a little off-topic here:

    Has anybody seen the new Star Trek movie yet? Cameron (Jennifer Morrison) is playing the character of Winona Kirk (James T. Kirk’s mom).

    Saw it last night, great movie, but probably not as good as a House movie. ;-)

    -mike

  103. Gardenator. The line was something like this….

    That’s not a pop belly, it’s a tumor. That’s why pancreatic cancer was in my mind. My brain was trying to tell me.

    Heishiro

  104. I am surprised that there were no references to “Dr. Strangelove” in this episode. POTW’s affliction reminded me of that excellent film.

  105. “though shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?”

    Remember, it was hinted in an earlier episode (season 3, the one with the marine, I forget the exact name) that Cuddy and House had slept together before; that might have been what Cuddy was referring to.

  106. I think House in a psychiatric hospital could be a great setting for the first couple of episodes in Season six… imagine some strange symptoms on other patients in that hospital and House diagnosing them to distract himself from the withdrawel… could be a blast!

  107. None of the possible causes mentioned is consistent with House’s symptoms – a vivid delirium, occuring both continuously and continually, yet with no mental deficits otherwise. In fact, I doubt any disease presents in such a manner. Nevertheless, this is consistent with the usual faulty disease presentations in the show, where symptoms seem to occur in isolation without affecting general health (as in this POTW who has liver failure to the extent that serum ammonia is present, yet excepting specific stated symptoms, seems to be in remarkably good general health). In fact, this is reminiscient of the similiarly unlikely Ukrainian female patient who hallucinated her dead mother. So allowing this ridiculousness, here are other objections to the major diagnoses offered in the above posts:

    1. Opioid-Induced Neurotoxicity. This exists. It is unknown why it occurs, but the leading hypothesis is accumulation of toxic neuroexcitatory metabolites (many nor- metabolites are neuroexcitatory). The solution is reducing the opioid dose, and/or rotation to a different opioid (as has been mentioned many times, House shouldn’t be on Vicodin anyway). Withdrawal is not the solution, and pain patients do need their medication. This is easily manageable and doesn’t require hospitalization, least of all a psychiatric hospital.

    2. Encephalopathy secondary to liver failure caused by acetaminophen (AKA paracetamol, the active agent in Tylenol and an additive to the hydrocodone opioid in Vicodin). House would be in terrible general health with liver failure. It would’ve been easily uncovered with liver enzyme blood tests, which surely must have been performed. A psychiatric hospital would not be appropriate.

    3. Schizophrenia. The age of onset might be unusual, but that doesn’t make it impossible, just uncommon (not nearly as rare as many of the diagnoses made on the show). Also, House’s behaviour is consistent with latent shcizophrenia. The major problem is that the writers might have a difficult time getting out of this. How is House to continue practising medicine? (actually, creative answers to this question might make for a good sixth season) Antipsychotic medication has terrible side effects, including detrimental effects on alertness and cognition.

    What other options do we have? Brain tumors. Brain infections. Epilepsy. Maybe effects from repeated brain trauma? (such as that little bump from the bus crash).

    Another note: the writers seem to have a psuedoscientific mythical perception of the subconscious. It knows everything, it doesn’t forget. The patient’s right brain somehow knows the deoderant is the culprit. It also somehow understands the conversation between the doctors and likes the suggestion that the patient announce things to it. The patient with “Mirror Syndrome” also seemed to magically understand the inner feelings of everyone around him. House has a hallucination representing his subconscious, and rather than it being a rambling incoherent associative synaesthetic entity, it is a coherent sagacious (omniscient?) being with concrete “suppressed” drives and desires. It’s all very Freudian/Jungian. Bleah.

  108. Cuddy should hire the right side of the patient’s brain, as it is obviously a skilled diagnostician…

  109. Love the reviews, read them religiously.

    Small correction: After House noticed the “ammonia breath” it was not caput medusa on his abdomen, but a big ole’ spider angioma (imho). I believe the lesion is shown off center and near the waistline.

    So it’s just another long term consequence of liver failure that should have been picked on the team’s original physical exam.

  110. I’ve been wondering if everything from the previous episode’s scene of Wilson and House in the car to Monday’s scene of the two in the car was hallucination/delusion.

  111. jojo
    May 12th, 2009 at 1:51 am
    My big question is how did his right hemisphere know that the deodorant was causing the symptoms?
    _______________________________________

    Because the right brain is much better at making intuitive connections than the left. It picked up subtle clues his left brain missed.

  112. Arlan
    May 12th, 2009 at 12:45 am
    In the end i had no idea what actually happened, he never slept with her? She never helped him?
    _______________________________________

    Not only did he not sleep with her and she never helped him, but he never even stopped taking the Vicodin. He hallucinated that part as well–he continued to take it while thinking he had quit.

  113. Propolene glycol is used as a food additive and as a food-safe antifreeze. It’s relative is ethylene glycol which is the antifreeze used in vehicles and is highly toxic. It’s very unlikely he could have absorbed/ingested enough to cause that level of harm, even using the spray (deodorants still come in spray form??) several times a day for years.

  114. I love the lack of clarity they’ve had going ever since House started hallucinating. That’s the whole point of the last few episodes: what’s real? The hallucinations of Amber were obviously hallucinations; she was dead. The hallucinations of Cuddy were still possible… House’s brain (heart?) was trying SO hard to get around the concept of the addiction affecting his performance that it finally brought on a full on, no holds barred hallucination that he couldn’t distinguish from reality. That was all he had left; that or the insanity brought on by the Vicodin. And if he ‘needs’ the Vicodin so much… well, there you are. He created a reality in which it was acceptable, because it wasn’t drugs anymore. What Wilson said about Cuddy replacing the drugs was very telling; that’s precisely what House’s brain was presenting him with.

    I was stunned by Hugh Laurie’s acting in the final scenes. I’ve never seen House look so broken as he did when they walked into Wilson’s office. Not a great episode, but a good one considering. Can’t wait to see where it goes.

  115. I’m still stunned by the final episode. I also almost crap my pants when I saw Amber, and I barely dropped the coffe mug. I personally think that the image of everybody enjoying Chase an Cameron’s marriage while Wilson stood in the rain as House entered the psichyatric was sublime. I almost couldn’t stop crying.

  116. The writers are leaving it to us to speculate about all this: where the hallucinations actually began: a week ago, a season ago. That’s all to play out. Genius.

    I was a little slow to sense something off, but I definitely hit the brakes when Cuddy very angrily shouted down & fired House because of “zero tolerance” for sex talk….and then, practically the next minute, they’re in her office and she’s smiling, almost apologetic about overreacting.

    Was she really referring to the baby comment of a previous episode? We don’t know! Did this conversation even take place? We don’t know!

    In any case, such a quick turnaround just seemed totally out of bounds for both the situation and the character. Now I see why.

  117. Excellent twist at the end. Its pretty ironic that this whole season has been hit and miss story elements…and then as soon as we accept it BAM…it was all it in his mind; but how much? Deserves repeated watching. Every episode since the bus crash probably has clues.

    Next season will be very interesting because he could be in the psych for several episodes. I can definitely see House in his gown standing in the hallway on the phone with Foreman; in an unofficial capacity, of course. He just can’t stay away from the mysteries…

  118. I think House is going to be in the psychiatric hospital for at least a few episodes next season, I found this link that says they’re going to be filming in there: http://www.nj.com/news/index.ssf/2009/04/tv_show_house_to_film_at_greys.html

  119. this is probably the best episode ever, even better than 4-15 “House’s Head”, the
    ending scene was one of the best, i ever saw

  120. Daniel.

    If House has Schizophrenia you asked how is House to continue practising medicine?

    That should be House dream coming true. In Season 3 (Son of a coma guy) the guy asks House why is he a Doctor, why work with people when obviously he is not a “people person”. He told a story about a friend of his when he was in Japan that had an injury, and they took him to the hospital. There, they passed a janitor, and the doctors didn’t know what to do with the infection, and they called the janitor that was really a doctor. A baracku (or something like that he said). People in the hospital only called him when they needed him cause “he was right”…

    I guess the writers should have something planned for House getting into that mental institution. Perhaps at the end it’s just as someone else said, he was psychotic because of the acetaminofen… Who knows. We’ll have to wait for that one.

    Heishiro

  121. Yet Another first time poster, here. Great Site.

    I’m aware that there is a degree of lateralization in brain function, and even more aware of how it tends to get blown way out of proportion. I’m surprised no one picked up on this at all – was the team exaggerating the patient’s lateralization, or not?

  122. I can’t believe!!!! They played the “6th sense” card.
    I mean… there were no dead people, but still… He was hallucinating and the director didn’t portrayed that?!?!?!

  123. YenTheFirst:

    Oh yes. I’m not an expert, but it definitely seemed the shallow decisive imputed functions and capabilities of each hemisphere was another example of the writers’ engaging in pseudoscience. They really want House to represent a brilliant rigorously rational medical expert, but it’s obvious the writers are not familiar with this mode of thought (the worst offenses are not when they get various facts wrong, but the frequent displays of deep lack of comprehension of the scientific method, rational skepticism and investigative protocols). On the other hand, they have quite witty people on staff, letting those verbal sparks loose (love some of the episode titles involving multi-level puns, such as ‘Lines in the Sand’, ‘Cane and Able’, etc.)

    By the way, I’d rather expect House, as an amateur musician, would be appreciative of the right hemisphere and interhemispherical integration.

  124. For me it was awfull ending of one compeatly week season (well maybe the show deserve this). First tought after watching episode no. 24 was, that writhers of the House M.D. show does a lousy job, and it look to me like this final episode was made in some half an hour in writhing the story! It was too forced scenes and too forced situations that remains unanswered.
    House halutination was OK solution for writhers, but at the same time a bit expected and “deja vu”.
    What about Cammeron and Chace part? They split, then get together, then split, brake, split, marry. I can`t bealive that one sperm sample could ruin their connection. Another very week part of this season 5. I sincerilly never sence some love conections between them, and this fast marrige was result of very bad scenario that writers force past several mounth`s.
    Kutner suicide was never really racional and justified, and it`s another forced solution for writhers to say good buy to Kal Penn. Again his act doesn`t have real meaning in past or future from his suicide.
    Long story short… This season scenario for House M.D was bad, less inteligent, brake apart all over and it give me feeling like it`s writhen very fast, and absolutely without some strong plot that will guide us through episodes.
    Really if someone ask me what was season 5 about? I wouldn`t know what to say.
    Kutner kill himself> Why?>I have no Idea
    What`s with 13th Huntington’s disease?>Not a clue
    What`s with Wilson and his emotions after Amber> nothing!
    ….
    For season 6 I would politely suggest different writhers of the show, who are obviously tired of making bealivable, but same time excithing basic story that will not interrupt at middle of the season, and end really poor!
    This episode doesen`t deserve to be seson final, and was way to worse compared with last season finale!

    For this episode I have very litlle positive things to say. I liked atmosphere in last 5 minutes… I liked “defeat” of House against Vicodin and addiction, I liked emotions in final scene…. and that`s it.
    I really figure it out that lipstick was vicodin really early, but I tought that House was already in mental institution (which imo, would be better story for season finale) and that he is hallutinating in some empty room fight with his rehabilitation!

    I said really negative things for this episode (that I really hopesaw that will turn the season in good ending), but I am addicted to House M.D and I will waiting for season 6, but not with same intensity like last year!

  125. “A baracku (or something like that he said). People in the hospital only called him when they needed him cause “he was right”…”

    The word you are looking for is buraku, or burakumin. They are people descended from “outcastes” of feudal Japan. Outcastes were made up of people with professions considered tainted by death such as executioners, undertakers and leather workers. Even now in some areas there is stigma associated with being a burakumin.

    As for House I’m pretty certain he has drug induced psychosis rather than schizophrenia. The symptoms fit psychosis better.

  126. Another option: metabolic disorders affecting the brain (a missing cofactor for whatever reason, or some genetically dysfunctional enzyme). Highly unlikely considering things, just including it for completion’s sake. Also, on second thought I shouldn’t have called House’s condition ‘delirium’; not the right term.

  127. I have to disagree. I think the soap opera deserves a Big Red F.

    I liked house because of the semi-real medicine and the LIGHT somewhat humorous (remember the courtroom scenes) soap. PLEASE don’t turn House into a new show.

  128. Great episode, of course. It is, however, tainted by the fact that like all good story arcs on House it will be forgotten about within the first five episodes of the next season and never mentioned again. I’m even more sure of this since they seem to be going with the vicodin induced psychosis diagnosis rather than the schizophrenia. Personally, I’d rather schizophrenia.

    The most annoying time that’s happened as of late was with the methadone. I really think it’s time House’s character had some sort of progression, ebcause everytime they hint at change it’s swiftly snatched away. This will dull the shock of any actual change they implement.

    PS- Doctors can practice with schizophrenia in some capacity… I saw a documantary about it, no source, just have to take my word for it!

  129. Did anybody notice that this season finale ended with a Rolling Stones song? That happened in season 1 as well. I don’t know about the other seasons, but there is pattern here.

  130. I have to say, I got a certain vindication out of seeing House’s soul completley destroyed.

    Despite the fact that a lot of he soap-section was a hallucination, I beleive his reaction to the hallucination was real. He really did want to get with Cuddy, and he really did want to be off the Vicodin in order to be with her. To suddenly find out that A: It was all a dream and B: he may have actually ruined his chances with Cuddy for all time… you could see it in his eyes. He was crushed to a metophorical pulp.

    I can see them following those plot lines in the next season. Unless they don’t of course, which would be annoying.

    I think House trying to have a serious realtionship, and deal with Cuddy’s child would be a fantastic side story. Bring on season 6

  131. First time reader and poster. Great site.

    I think the whole psychiatric ward scene was also dreamed: House and Wison missing the wedding? Ominous weather compared to the sunny day at the wedding, not a car or person on the street, not a leaf on a tree, a “cliche” looking building with burly orderlies waiting on the steps??? Too surreal.

  132. Ray, I also noticed the difference in the trees: at the wedding, everything was in bloom and green, and with House, all the trees were without leaves. Which leaves one question: was it the psychiatric ward scene that was dreamed – or was it the wedding scene?

  133. Or was it that they were both real, and the start contrast was just cinematography?

  134. If the patient’s right brain was so smart (picking up on the problem with the antiperspirant and such), does that mean it had a good reason for hitting the girlfriend?

  135. This was probably the best exploration of the confusion between hallucination and reality since “Jacob’s Ladder”. I think a better summing-up song for this episode and this season might have been the Beatles’ classic “Strawberry Fields”:

    Let me take you down, ’cause I’m going too…
    Strawberry Fields.
    Nothing is real.
    Nothing to get hung about…
    Strawberry Fields Forever.

    Living is easy with eyes closed…
    Misunderstanding all you see.
    Its getting hard to be someone,
    But it all works out.
    It doesn’t matter much to me.

    No one I think is in my tree.
    I mean it must be high or low…
    That is you can’t–you know –tune in but it’s all right.
    That is I think it’s not too bad.

    Always–no sometimes–think it’s me,
    But you know I know when it’s a dream.
    I think–er no–I mean–er yes but it’s all wrong…
    That is I think I disagree.

  136. “though shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?”

    take under consideration that Cuddy was not aware of the halucinations or any House’s health issue. She just thought he was okay – in his own way. She knew she hadn’t had sex with House and that was obvious to her that House was aware of that, too. Therefore there was no necessity on her part to say – “but you did NOT actually sleep with me”, the more so because she thought it was “just” his way.

  137. “So this is the story you made up about who you are. It’s a nice one, too bad it isn’t true.”

    that sent chills up my spine
    i ended up staring at the screen for several minutes after the episode finished thinking about that line over and over again

  138. Why did Cuddy not yell at House for lying as well as screaming her sex life to the lobby? I’m guessing that Cuddy misunderstood what House was saying. There have been hints dropped throughout all 5 seasons that House and Cuddy have had sex in the past, before the show even started.
    Oh, by the way, Dreufo, I think that only the detoxing and the sex were hallucinations, not the whole season.

  139. @daniel
    I generally agree with you about the season being hit-and-miss, but in all fairness, the kutner thing was kind of last-minute.

  140. Hi there, long time fan and lurker. Just my two cents:

    I think House’s downward spiral started with “The Softer Side.” He was on methadone, he was pain-free, but then he ended up causing iatrogenic complications in the dehydrated chromosomal mosaic patient, which he attributed to being–pain-free. In “Locked In” he ended up in that accident after a psychiatric appointment, which I’m thinking didn’t go very well. Then Kutner killed himself in “A Simple Explanation,” which for House was devastating because a) he never saw it coming and b) he couldn’t figure out why Kutner did it. The shock of Kutner’s suicide put things in motion.

    So we saw Amber at the end of “Saviors,” Amber who represented not only his subconscious, but also his remaining guilt over her death. He recognized she was not real, so he could cope, until he grew outright scared of her at the end of “A House Divided” when he unintentionally injured Chase. It was only then when he sought help from Wilson in “Under My Skin.” Except he screwed that up too because he lied to Wilson about whom he was hallucinating. House goes to Cuddy for backup support. In reality he insulted her baby and she walked out disgusted, but it was her walking away that triggered the delusion.

    I’m holding out for psychotic major depression because I didn’t get any sense of escalating drug use in the arc. Also he wasn’t showing any significant cognitive dysfunction which would point to schizophrenia.

    I also want to point out that everything in this episode, except the lipstick (which was the vicodin bottle), was real, until House relived his delusion in Cuddy’s office. Everything after that was real too.

    Whew. Awesome summaries, Scott!

  141. Okay, gotta say it:

    I had a momentary image of next season starting with House walking toward the psychiatric hospital, then stopping, clicking his heels three times and saying, “there’s no place like house, there’s no place like house.” Then waking up in the hospital (or in the ER after surgery, or at home in bed, or on the floor of his office) with the rest of the cast standing around him, all in b&w, and he saying, “it was a dream, and you were there, and you and you. . .”

    I agree that at this point, the writers could, theoretically, do a re-wind to just about any point in time, including the original surgery on his leg.

    I’ll weigh in on one other point. I’m not a doctor, but I am pretty certain that they won’t pin House’s problems on acetaminophen poisoning. It is inconceivable that House wouldn’t know the long-term problems with high dosage of acetaminophen. He would have switched to an alternate pain med with lower acetaminophen, but they use “vicodin” for the same reason they have House’s teams perform all their own tests and surgery. Viewers recognize “vicodin.” The writers use artistic license to set the story easier with fewer actors, but won’t cause House’s problems to something printed on the side of every Tylenol bottle.

  142. Since there was a lot said about House and that story I’m gonna move on to something else and point being surprised that nobody noticed how much Chase has grown and matured over the seasons.
    He started as infantile manipulated and lacking any confidence but now he is usually one of the best people in the room. That’s a great story of character development I think.

  143. Hello, long team reader, first post.
    I’m sorry if this point has already been evoked but why House is going to a psychiatric hospital without trying the detox cure..??
    Wilson in the previous episode says : “your vicodin levels are way too high” (it was underlined by Scott), so if the detox isn’t real, why doesn’t he try that before the psys ?
    Do we have to understand that the damages are too severe to be caused by Vicodin only ?

    Thank you for your answers and I apologize for my poor English !

  144. I really liked this ep. but I felt a bit confused.. I really didnt get what was hallucinations/delucions.

    What was hallucinatios/delucions in this ep?

    So he never said to cuddy that he needed her (or about his hallucinations)
    so then he never detoxed right? all that with him throwing up and stuff, was that an hallucination aswell?

    and How much of this ep was a hallucination?

    was him telling wilson about him cuddy having sex a hallucination?
    was his patients a hallucination?
    so then him and cuddy speaking about them just having a proffesional relationship a hallucination?
    the patients the whole ep?? :S

    aarghhh I get so confused :S I hate it when they do this, I want it all clear and black and white and explained… -_-

    ooh and btw, House could have schizofrenia, sure, its usally shown in early adulthood (20+) but (correct me if Im wrong) drug abuse can make you develop schizofrenia.

    I would really love it if someone could explain this for me =)

  145. Although i disagree with your opinion about this episode in general (in my opinion it is one of the best house episodes at all) i think your medical rewies are very interesting and nice to read. thank you!

  146. Thanks for the review. I, like many others, thought this was a decent enough episode until the last five minutes or so made it, and last episode, retroactively amazing. A few questions on the medicine, though.

    1) Does it make any sense to add PTSD to the list of possible causes for House’s hallucinations (along with the suggestions of opioid-induced neurotoxicity and uncommonly late-onset schizophrenia)? We have a list of prior traumas to choose from (hinted childhood abuse, the infarction, getting shot, the bus accident and its fall-out, even the death of his father), and Kutner’s suicide may have been the trigger for the psychosis…

    2) I may be misremembering case law, but wouldn’t it be illegal for the state medical board to ban House from practicing medicine because of an addiction or mental health issues (at the same level as discrimination against physical disability)? I mean, after he demonstrates that he can still function as a doctor (I’m imagining his team barging in on his treatment at Mayfield and asking for help on a case, just to show him and the board that he hasn’t lost his mojo). Or do you think there would be a rather drawn-out process for him to return to work? Though I suppose his position at PPTH is a separate issue from retaining a medical license (again, having tenure, could Cuddy actually fire him just like that? I seem to remember something from the Vogler days about needing unanimous board approval, and he does have Wilson on his side).

    3) If the hallucinations ARE due to opioid use, what do you think the safest and most effective non-opioid chronic pain management would entail? I’m guessing antidepressants coupled with something else, right? That is, if the writers don’t totally screw us over re: pain management issues and suggest that House has NO pain after the Vicodin detox because it had all been linked to his addiction. As much as I “like” the guy, I’d hate to see him truly pain-free if it meant taking a cheap shot at chronic pain management issues.

  147. You know, it occurs to me that Kutner’s line, “So this is the story you made up about who you are. It’s a nice one, too bad it isn’t true.” could be interpreted to mean that the entire series has been one long hallucination?

  148. @Morfolk:

    Really? Chase has been annoying the hell out of me this season. Yeah, he did the right thing in the end, but it took an episode and a half of him acting like a complete jerk and putting his fiancee through the wringer for him to man up.

    (Of course, Cameron’s poor articulation of her feelings certainly didn’t help things, so she’s not completely blameless. But she has a much better excuse for her hangup in this case than Chase does.)

  149. I was just about to submit: “Could you please start using red, *yellow* and green? It’s what the rest of us are used to, you know.” and then I decided to check. Things on occasion not being exactly identical all over the world and all. So I look it up on *Wikipedia* and what does it say? It’s not yellow, it’s amber. Amber? Amber?! WTF?!

  150. Well, what if House only thought that Cuddy committed perjury for him in Season 3, and he’s really in prison, and everything for the past few years has been just a hallucination?

  151. does that mean it had a good reason for hitting the girlfriend?
    I think the left hand was upset with her (so to speak) for bringing the deodorant and smacked her as a warning to her or the doctors or “in self defence”, Hank, just like it angrily threw away the spray can.

  152. I don’t know if someone has already said this, or if it’s even relevant anymore, but I just want to point out that checking yourself into a psych ward and being committed are totally different things. As far as I understood, House was not committed. therefore will not have the ramifications of being sanctioned.

  153. I agree completely with the review. The original patient’s case just seemed to be shrugged off and forgotten in order to throw in the final twist at the end. I pretty much figured within about 15 minutes of the episode that House did not actually detox, after all, he supposedly detoxed from his heavy, prolonged doses of Vicodin over night, something that takes anywhere from 5 to 7 days to get through, and the worst WD symptoms don’t usually hit for 3 days. (I suffer from chronic acute pain due to an undiagnosed intestinal disease, and I’ve been taking Hydro/Oxy for 5 years… addiction is a bitch) Another thing, as many pills as House takes on a daily basis, wouldn’t you think he would be dead due to the APAP overuse causing jaundice/liver failure before the hallucinations/delusions occured? Anyway, I’m still really excited about the next season, Mr. Laurie is an absolute genius, and aside from that, the sex appeal added by Dr. Cuddy and Thirteen (congrats for making number 1 on this year’s Maxim hot 100 Olivia!) is just too good for a 16 year old guy like me to pass up. Best show on TV by far.

  154. At least one person managed to pick up what the writers were practicly trowing in our face – WHAT HOUSE REALLY WANTS! I mean if he was seeing a shrink earlier, so he at least admits he is confused – he is looking for answers any possible way because he can understand that he is in the deep. And when his subconciousness got out in the open at least he knew and understood what he really wanted – to be pain free or at least without the worst part of the pain, but whitout the Vicodin (or any other drug like methadone for example) to be wiht Cuddy even live with her and have a real relationship out in the open (Shouting from the balcony to the entire hospital was real – his Motives were true even if they started from a false assumption) I think the autors should consider giving him a line out of his drug saturated everyday live – and I really can’t see any possible way for him to get back to the Vicodin popping unless of course they play the “nothing was real card”. I just remebered the fisrt episode from season 3 – he was pain free he was jogging and happy he was trying all the new things he couldn’t do before and he was still House – brilliant and nailing the diagnose from zero facts. So he can do it he should do it and some happy ending is in order here for season 6 – fingers and toes crossed.
    On the side note about Chase – he was my favorite char from seasons 1-3. The way he grew has incredible the way he always thought outside the box (he was/is the most House like in that – diagnostically brilliant), the way he finally managed to get the girl – and keep her despite recieiving damaged goods! was unbilievable. Cameron is one lucky girl tha’s for sure – and he gave her so much always beiing reasonable always making the compromise just to make it work always ready to step back even when she submitted to his whims jsut to make sure she is happy. My one sincere regret is that he doesn’t want to go back to the team – he would of made a great new House – way better than Foreman. And sice we are on the subject – the depatment of diagnostics is now a member short – who will be boss? and who will fill in the crew if Foreman is boss? I think tha actually presents some interesting story lines – such as Wilson head of the department, Cuddy trying to rally the young guns behind her, Foreman recruiting a new fellow, Chase being in charge and Foreman being subbordinate, Cameron jumping back to being the do-it-all – all fun all good…We can even make a challenge about this – how will the department be organised while House is away.

  155. I DVR’ed this entire season of house, and just re-watched the bus crash episode. House dreams Amber in that episode, it’s eerily similar to his hallucinating her, and she helps him find out what’s wrong with her. He also has deep brain stimulation done to help recover his memories, and goes into a coma for something like four days as a result. It would be really interesting if that plays into the solution/problem.

    It’s just exciting to me, thinking about what they might do with this, because there have been moments this season where it felt like House was jumping the shark a little. How much of it will end up having actually taken place?

  156. *Edit- Coma never happened, or if one did it’s not the one I remembered. The four day coma is from Bones, which had an equally interesting finale. Either way, definite catharsis!

  157. Eric : Was the scene where Cuddy pulls House away “to talk” real? House makes the comment: “Isn’t that like locking the barn door after the horse has put is face between your breasts for an hour and a half?”

    Cuddy doesn’t seem confused at all by the statement. Because it was the two of them alone, it feasibly could have been another invented memory in place of what they really talked about. Hopefully they’ll do a commentary on this episode for the DVD, and we’ll get a full explanation.

    I went back and re-watched every Cuddy scene in that episode, and it turns out they make do perfect sense from her point of view. Her whole attitude is because he insulted her the previous day (the “suckling your bastard child” comment), it was the last straw, and she decided to give up on him.

    The comment about the horse putting its face between her breasts for half an hour turns out not to be jarring in that context, because really, House is always doing sexual innuendo with Cuddy. It looks like him being his usual asshole self, which just makes it that much more delicious when you know what he’s really thinking.

    The only bit I thought was a bit contrived was, as others pointed out, when she gets angry about him talking about her sex life as opposed to lying about it… But if they had a one-night stand long ago that also makes good sense.

    Basically, he knows something is wrong when he finds out about the pancreatic cancer, but he only realizes he hallucinated the end of last episode when Cuddy clearly says she’s angry about his insulting her the day before and says “not only we don’t have a personal relationship, we never could”. At that point the illusion can’t continue anymore.

    If he’d been hallucinating conversations with Cuddy that day there wouldn’t be such an obvious point of no return.

    So I don’t think any of the Cuddy scenes in this episode were hallucinations.

  158. You can’t practice medicine if you’re diagnosed with schizophrenia. They revoke your medical license, and it’d be easier to fly a kite to the moon than to get it back. When you’re proven to be unsafe, they don’t let you see patients.

  159. House’s diagnosis of the Carl Reiner character was irresponsible and specious. I have exactly the same symptoms as that man, and it’s not due to pancreatic cancer (yikes!) but to chronic intestinal pseudo-obstruction. Before a doctor makes such a frightening assertion to a patient, shouldn’t he rule out more benign conditions first? That character looked like he was about to die of shock! An 80-year-old could easily have a stroke or cardiac event from such an ordeal.

    I know it’s just fiction, but many people think House is “real medicine.” The many people with IBS or motility disorders might be alarmed by that episode.

  160. While the ending was a great and unexpected twist, I must admit that the moment that Amber and Kutner appeared, made me think it’s all much more twisty. First I thought “House killed Kutner and now he’ll rememeber that” and right after that “House is insane, he’s not a doctor at all, he’s probably locked in some mental hospital”. Reading too much into things, I believe.

  161. i find that it is interesting that house got admitted to the hospital that folk singer woody guthrie died in. woody died of huntingtons. seems like there might be a connection with that in the 6th season

  162. Can somebody say what was true and what was not? I couldn’t figure it out! It think every conversation between House and Cuddy and House and Wilson were hallucinations… Do you agree?

  163. If we’re going to allow the possibility that none of the series ever happened and house is a schizophrenic locked in a mental institution, then why not make house be one and the same as the other schizophrenic that we haven’t met – wilson’s brother?

  164. The horse/breasts comment still doesn’t make complete sense. When House made the comment, he was referring to Cuddy’s sudden change in attitude towards him (or so he thought). The comment makes a direct reference to him and her having sex recently, and I really don’t see any other way to interpret it. I guess Cuddy could have just brushed it off as nothing, but I still think it’s weird that she didn’t at least seem confused, even if she didn’t say anything. I’m just trying to think of what she could have thought the comment meant.

    Karen,
    Everything in this episode was real except the lipstick. The lipstick was really his Vicodin bottle. In the previous episode, Cuddy walked out the door after House insulted her. He never asked for help detoxing. Instead of detoxing and having sex with Cuddy, he really went home and popped pills.

    When House announced sex with Cuddy to the lobby, that was real. Cuddy thought he was referring to the hook-up that they had 20 years ago (which has been hinted at several times in the series).

    I think that about covers it, at least as far as I understand it.

  165. Another viewer did a very comprehensive summary of what was and wasn’t real in the last two episodes at http://www.imdb.com/title/tt0412142/board/thread/137781509.

    And all I have to say is that there ought to be a law against psychiatric hospitals looking like Norman Bates lives there! Poor House…

  166. Hey, this was supposed to be the season finale??? I´m almost disgusted. Yes, true, all the finales except season 1 were quite odd, but… Patient poisoned with deodorant, clinic patient with cancer, House hallucinating don´t know what all.
    1. As far as I can remember from toxicology lessons, propylene glycol is quite harmless in comparison to similar substances (ethylene glycol…) cause it can be easily metabolized to are lactic acid, pyruvic acid, acetaldehyde and acetate, all commonly found in human body. Of course, exceptions happen all the time in the world of medicine.
    2. Didn´t like Chase and Cam´s wedding, but at least it was less fancy than it´s usual in movies. Anyway, what´s Alison´s surname now? Chase or Cameron? And are they together ever forever or we´ll see their divorce in 6?
    3. House hallucinating detox and sex with Cuddy. Way too crazy, but he could hallucinate cutting his patient to pieces (No Reason) just from the trauma he just suffered, so perhaps… Some late onset posttraumatic hallucinatios or st.???
    4. House at psychiatric hospital? Wow if this part was real, wow if he hallucinated that. In my opinion, it was real and in 6×01 House in his typical housian mind comes right back either talking about it or pretending it never happened.
    5. Can´t wait till 6!!!

  167. Tks Eric and Rockethound!!
    But I’m still thinking about Wilson… He didn’t act as usual when he told House to do something strong against Cuddy… Wasn’t it a hallucination too? Was the whole talking between Wilson and House real??
    3 months and a half till the answer!!!!
    Tks!!!

  168. As to House’s hallucinations, in the second to last episode, House made a list of possible causes for his hallucinations – sleep apnea , infection, trauma, ms, and schizophrenia. They ruled out everything except for trauma before concluding that it was because of the pills. I think that is why he was seeing Amber in his hallucinations. They are being caused, at least in part, by the trauma from their bus accident and/or the procedures that were done on him while trying to save her.

    I don’t think the writers would have put trauma on the table if the cause was simply going to be the Vicodin.

  169. One thing about the right brain and the deoderant… it actually isn’t necessary for the right brain to “realize” the deoderant is the problem. It merely has to not like it. That it also happened to be the cause of the increased symptoms would simply be coincidence, that the girlfriend brought it up and set thoughts down that track.

    Given the nature of the information the right brain had to work on, it almost certainly could not have self-diagnosed this problem; the onset was far too slow and the possibilities far too numerous. (Being “intuitive” and “visual” doesn’t mean “magical”.)

  170. I just noticed that when House wakes up in the first few moments of the episode there is no lipstick on his face, but then in the bathroom seconds later he looks at a big lipstick print on his face. Pretty sneaky.

  171. Keyser Söze!

    Remember that Bryan Singer (director of the Usual Suspects) is creator/producer of House, and then maybe all the crazy bullshit will start to make sense.

  172. It’s still bullshit, though. They’ll never get better than Season 3.

  173. Benn:

    “You know, it occurs to me that Kutner’s line, “So this is the story you made up about who you are. It’s a nice one, too bad it isn’t true.” could be interpreted to mean that the entire series has been one long hallucination?”

    My jaw dropped at this. Haunting thought–and it actually makes MORE sense than “Kutner” referring to just the past episode or two–but no. No, surely they wouldn’t go there…?

  174. Everyone seems to want to jump to a diagnosis of schizophrenia for House but delusions and hallucinations don’t lead inescapably to one. Forget the onset issue, he has no other symptoms such as disorganised thoughts, paranoia, affective issues, thinking his limbs are floating off. He is socially isolated though, which fits the disease.

  175. Does anyone else remember when House had 3D animations of the medical conditions taking place? When House would (in an obvious concession to audience understanding) make detailed metaphors to explain patient symptoms? Yes, it doesn’t really “make sense” for him to give long analogies regarding a condition to fellow doctors (he could still give them to the patients!) but now I have so much trouble following the medical aspects that it is difficult to pay attention to these parts. Sort of makes me feel stupid (though I have no medical background of any kind).

    Well, sadly they got my attention with their chain-yanking about Chameron, but I’m pleased with the result. Chase’s ‘deduction’ was a bit too easy. They also got me with the ENTIRE Cuddy thing, which is embarassing. Regardless, a powerful conclusion! (Was that building CG’d in?)

    Though there is some ambiguity about House and Cuddy’s feelings at the conclusion, I am wondering where “Mad Cappellan” is blathering with his ears plugged about how incredibly stupid the “Huddy Shippers” are, as he desperately tries to convince himself he is a relationship expert and the House/Amber thing is the truth and not more “shipping”.

    I am bored so I will create some categories!
    There are however many kind of viewers I now think of:
    1. People who just watch the show
    2. People who are interested in the relationships but are in it for the sake of watching what happens
    3. People who think certain relationships are right and some are wrong (and possibly hate the writers for constant chain-jerking and changing the relationships just to throw cheap twists into the show)
    4. People who feel so strongly about their views on the relationships in the show that they will argue and tell other people they are “wrong”
    5. People who read/write fanfics about relationships that may or may not fit at all in the show’s story

    I’m not sure where I was going with this.

    Afterthought: hallucinating is a cheap free-all pass to change any aspect of anything that happens in any episode, which is unfair to the viewer. They could say at the begininning of season 7 that House is actually the Jewish clinic patient with pancreatic cancer and Cuddy is happily part of a polyamorous relationship circle with Foreteen and Taub’s wife

  176. First time poster, been reading reviews a while, new fan to House.

    The moment that got me was the look of horror in his face when he opened his hand to find the Rx bottle instead of the lipstick. To see a man fall apart so fast is so sad.

    IF they start season 6 by fast forwarding to a recovered house, it will be a crime. I want to see everyone’s reaction when they hear where he is. I want to see his recovery and how he can bring himself to face cuddy again.

  177. “though shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?”

    she didn’t think he was lying, because they DID have a one night stand way way back…she assumed that he was reffering to that incident

  178. “The moment that got me was the look of horror in his face when he opened his hand to find the Rx bottle instead of the lipstick. To see a man fall apart so fast is so sad.
    IF they start season 6 by fast forwarding to a recovered house, it will be a crime. I want to see everyone’s reaction when they hear where he is. I want to see his recovery and how he can bring himself to face cuddy again.”

    Wayne, I completely agree. It would be far beyond a savage crime to fans and the series; we NEED to see House face his demons (no matter how painful and especially confront Cuddy about what he said and how he feels about her.

    I firmly know and have encountered someone who has broken down so quickly, and it is an awful sight to see. You feel so helpless and unable to process it. They did an excellent job on this; it conveyed every emotion and thought going through House’s head as well as Cuddy and Wilson.

    Season Five was overall one of my favorite seasons. Don’t get me wrong, I love the medicine of the previous seasons but ultimately the show centers around one guy (it’s not a far stretch of the imagination to assume this since the show is called “House, MD”). The last five minutes made up for any shortcomings in my mind even though I knew it was going to happen.

    I can’t wait for next season; it will be interesting to say the least. I know he will get his head back on, but the thing I’m excited and extremely anxious about is the whole Cuddy/House dilemma. That’s where our beloved genius’ fate lies. Hopefully, they won’t screw it up. But knowing Hollywood they will find some annal of idiocy to completely disfigure an otherwise brilliant storyline.

    This is kind of funny (and disturbing), but it would RUIN the entire premise of the show as well as the show itself.

    WHAT IF the entire series of House has been a hallucination. In fact, House could be a drooling, hunched over a wheel chair psychiatric patient who thinks that he’s a brilliant doctor who has many flaws. How sick would it be to end the series like that! I would protest indefinitely against any Fox production therein after. BE FOREWARNED DAVID SHORE, KATIE JACOBS, BRYAN SIGNER & HUGH LAURIE! Don’t screw it up. Puh, puh, please?

  179. Any chance the last three seasons were all a hallucination and House will wake up from his ketamine coma and the show gets back to what it was in the first two seasons? The original team never left, Thirteen never was hired, Amber is still alive and House/Cuddy is a bad dream?

    I admire you for still trying to explain the medicine on this show but I think Grey’s Anatomy is now doing more realistic medicine. I know psychology and GA certainly has more realistic psychology and character continuity.

    I’m now so tired of drama queen House and his enablers Wilson and Cuddy that I’d be happy if he stayed in the mental hospital. (Which was never explained satisfactorily either, if the hallucinations were vicodin overdose why isn’t he in detox and pain management? He doesn’t show the signs of incipient schizophrenia. Oh, wait, it’s going to be something totally made up again.)

    It’s now all about giving Hugh Laurie opportunities to show off his acting and not about good story telling.

    They certainly did a hatchet job they did on Cameron’s character in these last few episodes. After spending two seasons showing the Chase/Cameron relationship to be so dysfunctional it should failed already, the writers cap the destruction of the smart, self-aware Cameron by having her keep her dead husband’s sperm because of an emotional attachment to them. If they had left the explanation as because she was worried about the future, then both characters would have been reasonable, Cameron afraid for the future and Chase understanding. But they had to make her into a proto-psychopath for the shock effect and to make Chase look like a hero in contrast. (Not to mention that they went from Cameron saying “I met my husband just after he was diagnosed as terminal” in season 2 to “I didn’t know he was going to die” in season 5.)

    And that’s why the show has moved from medical mystery to now bad soap opera.

  180. Okay, here’s my take on the whole thing: House is really an English comedian who bumped his head during filming of Stuart Little in 2003 and has subsequently been having a double-dream sequence hallucination that he’s a doctor in the US. It all fits.

  181. Personally I think the “Enjoy yourself” scene in last ep was creepier. The way she was singing a capella in a dim light when House realize he’s not yet cured. And her laughter….
    Even so, I was strangely attracted to her in that scene… -.-
    Hope to see more of her in the next season.

  182. Well, Kerry, since you don’t like any aspect of the show now, you can always stop watching.

  183. I think it’s funny how some are discussing the viability of the hallucinations and delusions, saying that its not realistic.
    How many of the previous posters have actually experienced living through life this way?
    And as far as the medicine itself being unrealistic – let’s see…
    it’s a TV show, about a doctor, WHO CAN CURE EVERYONE!
    I don’t watch the show for realistic medicine, (although watching an English actor fake an American accent while pronouncing terminology that took most doctors YEARS to master is quite entertaining), I watch the show because Grey’s Anatomy and similar soap operas don’t do it for me.
    I like the mystery of House, and the medicine is a hell of a lot more intelligent than Grey’s – the primetime general hospital.
    I’ll take Alien Hand over “patient x”.
    If you don’t like it, Gossip Girl is on at the same time.

  184. >>”I think it’s funny how some are discussing the viability of the hallucinations and delusions, saying that its not realistic.
    How many of the previous posters have actually experienced living through life this way?”

    …they are unrealistic portrayals of real conditions. You could answer that no one has experienced living that way because it’s not an accurate portrayal. Everything is artistic/cinematic license at best; as with the hynosis from the previous season’s finale, they care more about driving the point across. Yes, you can settle in and accept that’s fiction, but you have to remember it’s fiction, and the problem is a lot of people don’t think when they watch television and now they will be throwing out their body spray and so on.

    >>”And as far as the medicine itself being unrealistic – let’s see…
    it’s a TV show, about a doctor, WHO CAN CURE EVERYONE!”
    That’s… great… There’s no point in even watching the show if that’s all there is to it. It’s like Superman; Superman is too perfect so they have to create increasingly outlandish scenarios for him to overcome and it just feels incredily forced and fake. House isn’t a damn superhero. “WHO CAN CURE EVERYONE” is just silly.

    >”although watching an English actor fake an American accent while pronouncing terminology that took most doctors YEARS to master is quite entertaining”
    …exactly what terms take doctors “years” to master? I think you greatly overestimate the difficulty of repeating a word.

  185. RE:Brett
    >>”. (I suffer from chronic acute pain due to an undiagnosed intestinal disease, and I’ve been taking Hydro/Oxy for 5 years… addiction is a bitch) Another thing, as many pills as House takes on a daily basis, wouldn’t you think he would be dead due to the APAP overuse causing jaundice/liver failure before the hallucinations/delusions occured? Anyway, I’m still really excited about the next season, Mr. Laurie is an absolute genius, and aside from that, the sex appeal added by Dr. Cuddy and Thirteen (congrats for making number 1 on this year’s Maxim hot 100 Olivia!) is just too good for a 16 year old guy like me to pass up. Best show on TV by far.”

    There are so many damn things wrong with this post I don’t know where to being.

    Uh… you started popping that when you were 11? They gave you pills for an “undiagnosed” disease you don’t understand or made up? You’re just trying to sound cool on the internet because that TOTALLY impresses people? Maybe you typed your age wrong.

    For the love of God don’t buy into Fox’s shallow “looks over everything” bullshit. That’s why our television shows are mostly garbage, all anyone cares about is looks and it’s all self-perpetuating. ARG. I wish I was on happy pills now.

  186. what is truely shocking, and perhaps scary, is that House was diagnosing a patient while he is euphoric, confabulated, and hallucinating. None of his team member noticed, not even his best friend Wilson. He could have killed the patient. And I believe this is what House most feared, (2nd being the return of hallucination of amber and kutner). It is perhaps comforting to know, that most people who are psychotic or going through a psychotic episode, generally do not connect to the world very well, and are often picked up.

    I am somewhat glad (although doubtfully) that House sought advice from Wilson re: hallucination, conducted lab tests, request Wilson’s assistance in doubling checking his decision-making were REAL. if he was confabulating even back then, the whole drug-induced TEN, dopamine induced Raynaud’s, the cardiac arrest for MRI, the AF induced atrial thrombosis, and all those horrible horrible medicines from previous episodes, could be mere objects of his crazy mind….

  187. I just rewatched the whole episode (with the excuse, if I needed one, that I had missed the first 10 min. or so in broadcast). Reading various posts above really helped me to follow what was going on, with the two patients as well as with House.

    In my opinion, the only hallucinations were the ones House understood at the end: lipstick/vicodin, Cuddy’s love/anger. The rest of the episode fit with the plot involving the patients and with House’s working towards being able to confront Cuddy and confront his own desire to be someone else. In particular, the locker-room discussion in which he asks the team “There’s only one thing that could cause squawking, right?” and then, in the midst of the discussion of the split-brain patient, says suddenly “Pancreatic cancer!” That is not hallucination but it is an example of a huge split between House’s intuition and his rationality. His left brain asks the question but does not understand the applicability of the answer he comes up with.

    Also, his attempt to solve the lipstick problem, while it is nightmarish, is also, as Wilson says, a way for his left brain to keep control of a situation that it does not understand.

    There is also Taub’s remark about the right brain being involved in recognizing faces. To me this fits somehow with the fact that House is creating (or losing control of) an alternate, intuitive self: his cast-iron-bitch self, who knows a lot but is also frighteningly cruel (as in the threat of poisoning Chase). He has always walked a fine line of allowing himself casual cruelty in a context where it would be accepted (as Cuddy says, he has insulted her often enough before). His imaginary April, though, goes for the jugular.

    This alternate self is also, in terms of facial recognition, the person Wilson loved. House remarks that Wilson is afraid of losing House’s friendship, but we have heard again and again that House is the one who is afraid to lose Wilson to April, afraid to lose Cuddy to the baby. He wants to be April, to be the baby, to have the full attention of those he needs. And what threw him over the edge into both a really cruel comment and a full-blown fantasy was Cuddy not responding to his need.

    This whole season, beginning with almost losing Wilson and going on to the death of his repressive father, House has been trying consciously to become more lovable, less alone. That was why he went on Methodone, wasn’t it? He wanted to be persuaded to go to Cuddy’s baby naming party. He wants to be “good” and loving or at least lovable, but there is that part of him that wants to slap people and throw things, too. But his diagnostic skills have suffered. Epiphanies are harder to come by.

    I am voting for residual brain damage from the bus accident and subsequent heroic efforts to “find” April. But this is complicated by House’s tentative desire to grow up–tentative because he is afraid that if he integrates his “selves” he will lose his diagnostic mojo.

  188. Just had to add–totally non-medical–when House arrives at his suite with the in his pocket, he is singing “clang, clang, clang went the trolley.” In the 2001 TV movie about Judy Garland, starring Judy Davis, Laurie plays Vincente Minelli directing her in the famous scene where she sings this song (in Meet Me in St. Louis).

  189. OK, one more. Someone mentioned Tylenol. The Fox website has Tylenol as the sponsor of this episode’s online version, at least on my viewing. So every 10 minutes or so I was treated to a dissolving capsule and the reassurance that it will make the pain go away (well, the headache).

    Irony?

  190. Just got caught up on Hulu. I was all set to start nitpicking (heparin when POTW can’t tolerate an IV–what, one shot is a magic cure?) and then I realized there’s really only one thing to say.

    Thank you, Scott.

  191. Can someone explain why House was trying to make Cuddy angry? I’ve watched the episode twice, and try as I might, I just don’t get it. Since much of the episode was devoted to this, I’d like to understand it: why he was doing it and what he was trying to accomplish. Thanks!

  192. I take more Hydrocodone than House….about 70-90mg a day
    and I have not ever had hallucinations…and I have took it for 5 years along with Oxycondone sometime too.
    I take 20mg at a time and nothing like that has happened except I go to sleep….and have some strange dreams.

  193. just finished watching the last episode and i was lost, but after reading some info from wikipedia….man, now that’s a shocker. great season. cant wait to watch the next one.

  194. @toxicbelly

    Woddie Guthrie didn’t die at Greystone, but he was treated there. One reference says he referred to it as ‘Gravestone’.

  195. Hello…..Anyone??……….Bueller…? :p

    I’m still looking for an answer (3rd time now):

    Is the facility House commits himself to the same one that Wilson’s brother was/is in?

    If it is, this would open a whole new direction for the writers to go in next season.

  196. Gregg, if you take 70mg of hydrocodone per day you’re taking 7000mg of acetaminophen–double the amount required for irreparable liver damage. (Having been through a biopsy for liver damage caused by acetaminophen, I now shake my head at House’s patients who chat, laugh, and play air guitar through liver biopsies. And that’s why I’ve switched to Vicoprofen, which still sucks but hopefully doesn’t cook my liver.)

  197. Everybody in Plainsboro seems to have forgotten that there is a drug which can cure House of his pain completely, and can therefore help him off vicodin. (as seen in an earlier episode this season, but I don’t know which).

    If the vicodin was a problem, House could just have taken that instead of go to rehab with Cuddy. But then the plot couldn’t have made this (awesome) twist.

  198. Judy, by April do you mean Amber?

    Marley,
    Don’t watch the show on Hulu. Fox’s streaming website Fox on Demand has high defintion video and real-time streaming with no buffering – much better than Hulu.

    Also, Fox actually responds when I contact their support, while Hulu doesn’t.

  199. @Marley, I finally got the answer I was looking for elsewhere but thanks for being helpful with the “idiots guide to google” link you provided. It inspired me immensely.

    Because Danny (Wilson’s Brother) is in the psych ward of New York Mercy & not Mayfield Psychiatric, there goes a plot direction I was hoping the writers may go in next season… oh well more to keep us guessing and posting in places like this until September I guess…

  200. I have already posted a long and extensive explanation of the human body adaptation potential. May be somebody should read out more about alcoholism for example and the fact the alcoholics have increased level of ethanol-dehydrogenaze – the enzime responsible for the metabolism of alcohol in the human body (the liver to be more precise) that is why they need increased amounts to get drunk after all. It goes the same for pain killers – when you use increased dosages for long periods of time you get adjusted. You need more and more to get the desired effect – that is because your organism produces increased amounts of the stuff you use to process drugs. THAT is my medical explanation about how exactly House (and apparently Gregg) are still alive instead of going through the pleasures of acute/chronic liver failure. BTW Gregg we had a long spat about God in one of the previous posts now right? The fact that U R on chronic pain meds explains sooooo much. I must apologize that I attacked your faith so cruelly. After all you need it – placebo or real it is apparently a “drug” U need. So my apologies again.

  201. I don’t think that medical reasoning is completely sound. I don’t know whether increased drug tolerance (i.e. needing more to get high) also increases the amount needed to cause physical damage, but I doubt it is an exact ratio. Are you saying an alcoholic who needs more liquor to get drunk will have a “stronger” liver and his body won’t be damaged by increased alcohol consumption? I think you are approaching this improperly. Besides which, symptoms are still symptoms – if he’s hallucinating, he’s taking WAY too much and should be experiencing physical damage as well. That’s like saying an alcoholic who keeps vomiting blood isnt in much danger because hes been drinking for a long time and his body is used to it. Besides, it’s just vomiting blood, his liver must be fine.

    “The fact that U R on chronic pain meds explains sooooo much. I must apologize that I attacked your faith so cruelly. After all you need it – placebo or real it is apparently a “drug” U need. So my apologies again.

    That is an incredibly rude and disrespectful thing to say. Your self-rightous patronizing is despicable; you should be barred from speaking.

  202. Dr. Scott – LOVE this site. My wife and I are ardent fans of House M.D. Thank you for having such a neat hobby that benefits us as well. :-) I love MANY of the other commenters, too … some of you guys/gals are awesome, it’s interesting to read the thoughts of people all over who are picking up on these odds and ends (clues, etc) in a given show AND throughout the season, and discussing them in detail, just as my wife and I do. Oh, and hats off to “M-II(ish)” for calling the hallucination early. :-) Nice!

    Okay … this is for “D-r Bulgaria” … are you a real doctor? Your screen name sorta implies that, as do the contents of many of your posts. If so, would you mind sharing with us what kind of doctor you are?

    Concerning this “adaptation potential” you’re discussing here … could you (along with Dr. Scott and/or others who are enough of an expert to confirm/deny, or others who just want to contribute) go into this a little deeper?

    First, forget the hydrocodone in the Vicodin pills for the rest of this discussion. I realize (and surely most of us here realize) that humans can build a tolerance to narcotics. That’s not what I wish to discuss.

    Instead I’d like to take a real-world look at the other ingredient in House’s precious little Vicodin pill (like many of you, I’ve often wondered why they don’t put him on a different medication that doesn’t have the potential to trash his liver, particularly since he is prone to abusing the drug … I share the opinion that the writers must want him to be taking something that viewers would be the most familiar with).

    For that matter, forget the TV show for a moment. Let’s just talk about the acetaminophen in the Vicodin.

    “D-r Bulgaria”, are you actually implying that the human body (i.e., the liver) can build a tolerance to acetaminophen (paracetamol)? Enough to allow the user to ingest toxic levels of THAT drug, without the toxic effects?

    If so, this has to be the first time I’ve ever heard or read such a statement from someone in the medical field.

    Note: I’m a mere computer programmer/analyst, and I did NOT stay in a Holiday Inn Express last night, so I claim no authority on these matters whatsoever. :-)

    Also, for those who are curious and wish to learn more about this subject, Google “acetaminophen overdose amount”, “acetaminophen poisoning and toxicity”, etc.

    Okay, forging onward; so in a 2008 book by ex-football player Jason Peter he claimed to have been taking 80 pills a day, including 60 Vicodin (plus harder stuff, plus alcohol, etc), for years. I didn’t believe this to be true — couldn’t imagine how it could be true. I thought it was sensationalism at best, lying through his teeth to sell books at worst. But that isn’t what bothered me. Lots of sportswriters discussed the book without ever wondering if it were true, so I worried that kids (or naive adults) who read/heard of Peter’s exploits might be misled just enough to hurt (or kill) themselves with an overdose. You know how it would go, “Hey, a few more won’t hurt us, Jason Peter took 60 Vikes a day, we can pop a couple more!”

    Because (and again, we’re ignoring the narcotic implications for now) it is my understanding that (some of the following was cribbed from somewhere at some point and now I can’t source it) hepatic toxicity may occur following ingestion of greater than 7.5 to 10 grams (24 regular-strength or 15 extra-strength Tylenol caplets or tablets) over a period of 8 hours or less, and THAT is just for a one-time OD. It is also my understanding that suffering a chronic overdose via taking too much acetaminophen on a daily basis can occur at far lower levels than that. It is also my understanding that alcoholic intake lowers the safe threshold.

    Note: the toxicity levels to which I refer assume that the overdose victim isn’t treated in time. One thing I believe we can safely assume concerning this discussion is that treatment for overdose isn’t on the table, because for the purposes of this discussion we’re talking about someone building up a tolerance … so that, in effect, there would no longer BE an overdose.

    So anyway back to Jason Peter; after doing some rough math (and being forced to guess at the dosage of the pills he was supposedly using), it appears that Peter was claiming to have taken, on a long-term basis, somewhere in the neighborhood of 20 – 30 grams (20,000mg – 30,000mg) of acetaminophen a day.

    Rubbish, right? Taking the equivalent of 40 to 60 extra-strength Tylenol pills in a single day? Doing that even once (without treatment) would have killed him, right?

    Well, a lot of people (none of whom were doctors, so far as i know) argued in multiple threads that it *was* possible for him to have done exactly as he said, for one reason or another. And one of their favorite fallback positions was that “he’d built up a tolerance” … which, naturally (given that Vicodin/Lortab is always combined with acetaminophen), would have to include a tolerace to acetaminophen …

    Most people who engaged in the discussion, including myself, argued that it wasn’t possible. I didn’t believe it then and I don’t believe it now. Please correct me if I’m missing something or if I’m mistaken here or even if the jury is still out on this: can the human body develop a tolerance to acetaminophen?

    Some of you may be wondering why this is important. Well, in the comments somebody (sorry I don’t remember who) was bemoaning people throwing away their body spray because of casual, carefree misinformation; I agree, and THIS kind of thing in the comments worries me a bit, too. Seems to me that certain kinds of misinformation (either it CAN hurt you, or it CAN’T hurt you) could be very dangerous, particularly to the naive and gullible among us.

    Oh, wow — hey “D-r Bulgaria”, I didn’t even notice what you said at the end of your post (your comment to Gregg) until just now.

    Wow. Just wow. I’m with Kevin on this, what you are implying with that comment is just … incredible. Bad form at a minimum …

    Anyway, for those who are still reading this overlong drivel, thanks for your time. I’d certainly like to read what other doctors / pharmacists / students reading this site think about tolerance and acetaminophen.

    Bill in TN

  203. RE: “80 pills a day”

    Rush Limbaugh was up to 30 OxyContin per diem before his last bust. Jason Peter probably had lower body mass (Hugh Laurie certainly does), but people can work themselves up to volumes that seem impossible to non-addicts.

  204. intresting, I really didnt know that vicodin contained paracetamol (they dont use vicodin here), with all his previous ODs why dosnt he ever suffers from a liver failiur kind of thing? (tbh I really dosnt know what u suffers from when u OD of paracetamol).

    I’ve a friend that pops citodon (I dont know the english term for it, or if there even is a english term, is a painkiller containing Codeine and paracetamol).

    anyways,she took 500 of these pills, and she said that everything was spinning and she went sick, and one nurse said something like “you almost killed your liver, thats why you feel like this”.

    So why isn’t House killing his liver? =)

    Oh and btw, if im not all that wrong, the reason they put paracetamol in everything (painkillers) arnt that to stop peoples from ODing? so its kinda like, u dont die of the ODing of the painkillers, more of the effect they have on your liver?

  205. Central Harlem Anonymous wrote:

    > Rush Limbaugh was up to 30 OxyContin per diem before his last bust. Jason Peter probably had lower body mass (Hugh Laurie certainly does)

    Maybe I should have specified this (I didn’t think it made any difference since the overall discussion is acetaminophen toxicity), but when these events transpired Jason Peter was a defensive end for the Carolina Panthers; 6 foot 4 inches, 295 pounds. His body mass was (and is) considerable; also, at the time, he was in terrific physical shape. Having said that, none of this matters to me in terms of this issue (more below).

    > but people can work themselves up to volumes that seem impossible to non-addicts.

    Again, I really don’t want to confuse these issues; we realize that people can build a tolerance to certain substances. Anyone who has seen a lifelong alcoholic go through a case of beer in nothing flat, without appearing to suffer many side effects (looks and acts sober after drinking a washtub’s worth), can testify to that.

    So for instance if a 300 pound football player says that he can drink a a case of beer and two liters of 80-proof whiskey in a 24 hour period, I would be far more inclined to believe him — alcohol tolerance built over a number of years of abuse + a very large body mass = far more intake potential than average. In college I spent some time around folks (and some of them were not big people) who could put it away as if they were storing it in a wooden leg then spend an hour debating world politics and current events. Without slurring a word.

    Furthermore, and please correct me if I’m wrong, but it is my understanding that tolerance to narcotics (opiates) can develop indefinitely — as in, there IS such a thing as “too much”, but that level will depend entirely on the given person/patient and how much tolerance they’ve built up.

    But again, I’m not questioning any of that. Peter said that he took 60 Vicodin pills a day. He didn’t say “painkillers”, he specifically cited Vicodin, which triggered the BS flag for me: forget the hydrocodone, that’s way too much acetaminophen (at least as I understand this issue).

    So again, what I am asking, specifically, is this: can the human body develop a tolerance to acetaminophen (without regard to the subject’s body mass)?

  206. A serious doctor rating web site that includes our Gregory House just for fun. Some of the ratings are quite funny.

    http://www.ratemds.com/doctor-ratings/99449/NJ/Plainsboro/House

  207. Hey I have a theory. When amber died house did all those things to try to figure out what happened and who was on the bus. If i remember correctly he did that electro therapy. Maybe that messed up his brain more then anyone thought. maybe thats why he is having the problems he is having. and all the meds he keeps changing, vic then methadone etc. I can’t wait till next season to see what happens. I hope that maybe Kutner comes back to “talk to house” about his death. even though kutner would be like house’s conscience but a way to accept his loss.

  208. I am a dental doctor (that is the European term for dentists now anyway). I have studied medicine all the way throughout my training as a dentist because that is a requirement in my country. I have also studied pharmacy for an year and a half internal medicine for an year intensive medicine for two years (scattered through other disciplines such as general surgery). And I am a fervent reader of medical literature on Quintecence publishing Inc. (that is a medical studies/publications paid online library for those who do not know that). So I think I have the credentials (as it turns out I am even liscenced to practice in the UK 10x to the health crisis there :). Now I have no time to repeat myself or to explain again all the things I said about Vicodin abuse (I explained them in a post in a previous episode review but I do not remember which one so just browse around if you are curious). I am well aware of the liver implications that acetaminophene abuse causes. As for adjustment – well I used the term loosely because I am not sure how medically qualified are people here about understanding more complicated medical terms. I’ll try to put it simple again while answering my opponents (but before that I’ll apologize to Gregg about my remark conserning God and painkillers – I was doing a bad House impression and apparently it was not funny – so I am sorry about that. A good discussion should not be marred with personal attacks or anti religious remarks. It was also foolish from my part to play down people with chronic pain so my apologies for that too. I am suffering from chronic pain in my right leg myself which is nerve connected (chronic ischiatic nerve syndrome is called in Bulgaria) it is a chronic inflamation of the nerve induced by reduced blood flow there. Since I feel well enough throughout most of the time I do not require pain meds. Physical activities actually reduce the symptoms so I am a regular jogger. During acute phazes I usually pop a couple of ibuprofens and soak it in a hot tub and that is enough. May be that is why I downplay people who need to pop pain pills every day but it is still no excuse for me. OK to medicine:
    1. Alcoholics do not have a “stronger” liver. They have increased tolerance against the toxic actions of alcohol but on the expense of the liver getting damaged. Google cirrhosis for details
    2. Increased tolerance towards toxic substances is a very common evolutionary mechanism overall. I’ll point out two very “non medical” cases that are well known to everybody – snake bite for people who are in contact with snakes all the time. A regular dosage of a certain snake venom would kill a regular person – they’ll be like a bee sting for an experienced snake handler. Swallowing small amounts of arsenic increases resistance to said poison two to three times. As a result it was used even in ancient times to prevent oneself from being poisoned – by building you resistance you get non susceptible to toxic effects.
    3. If you work with people who have serious health problems all the time you would get amazed about the feats a human body can accomplish. I witnessed myself full recovery from a nearly impossible situation 10x to a minimal intervention from a d-r’s part – yet it was that minimal effort that tips the scales in favor of the good outcome. The human body is truly miraculous thing – one should study it for years before starting to state strong words like “impossible!’ and “never”(I do not use those words and do not like them at all by the way – no medic should IMO)
    I’ll be happy to reply to other questions all the time – just bear in mind that like D-r Scott here I do not try to medically justify a TV show – merely explain it the best possible way. And whenever it starts sounding impossible (and that is another word I do not use when I practice because nothing is) remind yourself – it is just TV!

  209. After I red my post I came to the conclusion that I said too much on some subjects and not enough on others. I’ll point your attention towards two wikipedia article about paracetamol toxicity and individual resistance towards the toxic effects:
    http://en.wikipedia.org/wiki/Paracetamol (pay special attention to the paragraph about methabolism!)
    http://en.wikipedia.org/wiki/Paracetamol_toxicity
    Right now in my country the high school proms are “on fire”. As a result the toxicologie wings of hospitals are full with poisoned 18 years-olds. As a result I suddenly recalled a lecture of Bio-chemistry where the lecturer professor gave an interesting example about individual resistance towards alcohol: “You take a bottle of single malz scotch highest quality – no “toxic” ingredients whatsoever. You give it to a 18 years old boy on a prom night who alomost never drunk anything before and he gulps it in like 20 minutes. 24 hours later he is half dead (all dead without medical help). You give the same bottle to a drunkard beggar on the street who is like 70 years old. He gulps it of and walks away without even messing his steps. His liver is shot long time ago but his alcohol-enzyme levels are so high he cannot even get drunk. At the same time the youngster has a liver in perfect condition but is not ready to metabolize so much poison in so little time so he dies. Is my Housesque metaphor clear enough?

  210. Eileen : they just aired that episode here yesterday :). to figured out what happened to the person he new was dying he tried some hypnosis, and stuff, the last thing he tried was when he recreated the bus with the hospital personal in it and took loads of some Alsheimers meds to “remember” the crash, his heart stoped at that time thou. (I think the electro therapy is a later episode, or maybe a erlier)

  211. When are we getting the challenge final scores? I know I did bad, just interested…

  212. Paracetamol is metabolised primarily in the liver, into non-toxic products. Three metabolic pathways are notable:

    * Glucuronidation is believed to account for 40% to two-thirds of the metabolism of paracetamol.[38]
    * Sulfation (sulfate conjugation) may account for 20–40%.[38]
    * N-hydroxylation and rearrangement, then GSH conjugation, accounts for less than 15%. The hepatic cytochrome P450 enzyme system metabolizes paracetamol, forming a minor yet significant alkylating metabolite known as NAPQI (N-acetyl-p-benzo-quinone imine).[39] NAPQI is then irreversibly conjugated with the sulfhydryl groups of glutathione.[39]

    All three pathways yield final products that are inactive, non-toxic, and eventually excreted by the kidneys. In the third pathway, however, the intermediate product NAPQI is toxic. NAPQI is primarily responsible for the toxic effects of paracetamol; this constitutes an excellent example of toxication.

    Production of NAPQI is due primarily to two isoenzymes of cytochrome P450: CYP2E1 and CYP1A2. The P450 gene is highly polymorphic, however, and individual differences in paracetamol toxicity are believed to be due to a third isoenzyme, CYP2D6. Genetic polymorphisms in CYP2D6 may contribute to significantly different rates of production of NAPQI. Furthermore, individuals can be classified as “extensive”, “ultrarapid”, and “poor” metabolizers (producers of NAPQI), depending on their levels of CYP2D6 expression. Although CYP2D6 metabolises paracetamol into NAPQI to a lesser extent than other P450 enzymes, its activity may contribute to paracetamol toxicity in extensive and ultrarapid metabolisers, and when paracetamol is taken at very large doses.[40] At usual doses, NAPQI is quickly detoxified by conjugation.[39] Following overdose, and possibly also in extensive and ultrarapid metabolizers, this detoxification pathway becomes saturated and consequently NAPQI accumulates.
    This a direct quote from wikipedia about the third pathway of metabolizing acetaminophene. Now for people without basic knowledge of pharmacy and pathophysiology the matter can be kind of blurry. I am not sure if I can even clarify it or make it more incomprehesible but I’ll do my best:
    1. Acetaminophene per se is not toxic itself – the products of it’s metabolism – those from the third path ARE.
    2. How much of the NAPQI (see above) is produced in a human body is an INDIVIDUAL treat (different for every human.
    3. As part of the GENERAL ADAPTATION SYNDROME (what is GAS – well that’s a whole new and complex chapter so google it if you are curious) the human body can increase or decrease the amount of NAPQI (and it can also increase or decrease the other two enzymes/paths) in accordance to external stimulae (such as slow regular increase in acetaminophene uptake – key word here is SLOW increase over the years).
    4. The metabolism has this unique trait that it usually takes the path of least resistance so to speak – it adjusts itself to stimulae via the easiest possible way. It is an evolutionary imperative that usually (but not always!) works out to our advantage. It also works on the general feedback mechanism – stimulus – reaction – adjustment to compensate; change in stimulus – reaction – readjustment. Hoping that I am still in the fields of understandable for all phisiology…
    5. To sum it up a toxic substance while toxic in the amount prescribed by a pharmaceutical company to the sellers can be (relatively) harmless for somebody who is using it for a long time and is slowly increasing the amount consumed. Bear in mind that while the liver itself can regenerate (If we cut half a liver and transplant it to another person the donor liver grows back to the full in time and the recipient liver also grows to a full size albeit at a slower rate) functional damage to the liver cells is irreversible (cirrhosis). So the junkie is still screwed in that matter (as is the alcoholic)
    I am starting to bore a lot of people here so I’ll just shut it now and gently wait to see the winner of the House challenge.

  213. D-r Bulgaria:

    I’ve noticed many serious errors in your posts before, so it’s nice to see someone call you on one finally. Although you’ve quoted various bits of information related to the topic at hand, you do not address the key issue: paracetamol/acetminophen is toxic at high doses, and a tolerance to it does *not* develop in any way remotely similar to the tolerance/dependence mechanisms inherent to G-Protein Coupled Receptors (the type of of receptor super-family to which the opioid receptors belong).

    The reason the paracetamol aspect is downplayed in the show is simple: it is a drug. Opiates, on the other hand, are “druuuuugs”, those evil nefarious intrinsically harmful substances the dangers of which TV shows routinely exaggerate to the point of absurdity.

    I’ve addressed the paracetamol possibility in a previous post in this thread. To recap, it cannot be a realistic explanation since House does not exhibit the symptoms of liver failure, hepatic encephalopathy would not manifest in the manner portrayed, it would’ve been diagnosed quickly instead of being a medical mystery, and it is a very serious, life-threatening condition which requires intensive care – and certainly hospitalization in a psychiatric hospital is inappropriate.

    It seems the writers are going with the Opioid-Induced Neurotoxicity explanation, though that is similarly ridiculous.

  214. “Everybody in Plainsboro seems to have forgotten that there is a drug which can cure House of his pain completely, and can therefore help him off vicodin. (as seen in an earlier episode this season, but I don’t know which).”

    You mean Ketamine? There is an experimental protocol involving ketamine as an agent to ‘reboot’ some brain functions (I’m assuming the writers read scientific magazines regularly for things like that) but it would not necessarily be possible to do so more than once, especially since it didn’t ‘work’ the first time completely.

    Anyway, I loved the last 5 minutes of this episode. Yeah, it went down the same old ‘it’s a dream!’ cliche as almost every season, but in this case it wasn’t ALL a dream (just a very, very small part actually) and avoided what would have been a tailspin in the plot if House and Cuddy actually slept together. Either they’d have to not do it again, and then every episode would be about “oh, will they or won’t they?” or they WOULD do it again and it would wreck the show. There’s a reason that House’s ideal woman- or something close to it- couldn’t stay in the second season. House in a healthy relationship won’t work.

    Finally, as to the memory, I think a few people on here are underestimating just how strange human memory can be. People can alter memories easily, and end up remembering things that are far away from the truth. Normally it takes time and the changes aren’t drastic- an embellishment here, a slight alteration there- but if someone is on drugs, has altered consciousness, or is experiencing a psychotic break, these kinds of artifacts can just go further. Just an anecdote, but I know someone who has some of these types of memories- nothing like what was on this episode, to be sure, but she will remember things that simply did not happen, or happened completely differently. It’s not nearly as unlikely as other things on the show.

  215. I hope House doesn’t end up in the psychiatric hospital in Fox’s new show, Mental. Although it would be fun for a brief moment to see him beat up the new, iconoclast ,Patch Adams clone, New Zealander in charge of whatever he’s now in charge of at the hospital and then start coming onto the Cuddy clone who’s the hospital administrator.

  216. i was upset when i found out that house and cuddy didn,t really have sex together.

  217. “So this is the story you made up about who you are. It’s a nice one, too bad it isn’t true.”
    who said this kutner or amber?

  218. Amber said: “So this is the story you made up about who you are. It’s a nice one,”
    Kutner said: “too bad it isn’t true.”

  219. Daniel:

    Very well-said. I should add further that acetaminophen – like any drug – has potential for toxicity at sufficiently high doses. That such toxicity is due to the effects of metabolites is immaterial, and I’m not sure how tolerance could possibly develop (downregulating the CYP enzyme would cause lots of secondary problems).

  220. Josh:
    Indeed, the point is further emphasized by the fact that Opioid-Induced Neurotoxicity is also caused by metabolites. D-r Bulgaria’s assertion that organisms have a magical ability to develop tolerance to any xenobiotic substance is plain wrong, and such misinformation could even be dangerous. Tolerance develops due to specific biochemical mechanisms, which are generally well known (though the exact mechanistic details can be complex and are still being researched). Such mechanisms simply do not exist for acetaminophen. There could be some limited adaptation (a hormesis effect for general liver damage, for example), but someone taking increasing dosages of acetaminophen should expect to suffer from Dead Person Syndrome, not to become immune to it. The fact that the poisoning is due to toxication (harmful metabolites) is irrelevant; rather, that makes tolerance development all the more implausible – it is the body’s own detoxification efforts which are the culprit (and the liver does not have a means to somehow detect which enzyme pathway is causing the damage and downregulate it – I have no idea what D-r Bulgaria meant by “taking the path of least resistance”).

    By the way, since I’m posting again on this subject, might as well add some new gripes. These three serious errors are commonly seen in both TV and film. I’d love to see these addressed by Scott:

    1. Lack of distinction between intravenous, subcutaneous and intramuscular injection. On House there have been several such occurences: a syringe is just stuck haphazardly into a patient/victim (obviously not an intravenous shot), yet the medication within takes effect immediately.

    2. Lack of adverse effects from strangulation, save for shortness of breath. I’ve seen this countless times: a person is strangled by a strong person, on the brink of passing out, but is saved at the last second. After a few deep breaths, they’re back to normal. In reality, putting such pressure around the neck can cause a variety of serious tissue damage, resulting in long-term damage (possibly death?).

    3. Hitting someone on the head is not the same as handing them a sleeping pill. It’s an unreliable method of knocking someone out, and unconsciousness due to brain trauma is a pretty serious event.

  221. Oh, give me a break. This is NOT schizophrenia. The hallmark of schizophrenia is that it is a thought disorder. As soon as House opened his mouth everyone would know he had (at this age???) developed schizophrenia. They would not have even had to know that he was hallucinating. That’s because the way that schizophrenics think (and talk) is much, much more obvious than the fact that they hallucinate. And the split in “schizo” is the split between thought and affect. House’s emotional reactions to what he is perceiving (even if he is hallucinating them) are appropriate. And before schizophrenia develops in an adult problems are massively obvious before then. House is a self-absorbed asshole who is addicted to Vicodin and acts very much like a typical junkie but there are no obvious developmental problems with him.

    The medicine in House is often overstated and specious — as when House decides that flailing was caused by stimulants. Presumeably he would know that tics are not caused by stimulants, they are associated with stimulants because in Tourettes ADHD symptoms appear first, and are treated first (with stimulants) and then tics appear — but not because the kid is taking stimulants but because that is the natural course of Tourettes. A kid who has Tourettes, you can increase his stimulant dose and not increase the tics.

    I wish the medicine would be at least close to approximating reality.

  222. Shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?).

    Well it was confirmed in a previous episode that they had had a one night stand prior to the beginning of the series so from her point of view it would seem like he was using that event to publicly embarass her.

  223. I too enjoyed the last five minutes of the last episode of the 5th series more than the whole of the rest of this series, which struck me as fragmented and disconnected in every respect, medical or otherwise. The sex-scenes with Cuddy were obviously hallucinatory. Only an idiot (to drift into House-style) could have failed to notice that. House has been behaving like an idiot (rather than the usual jerk) throughout this series. Maybe the whole series, therefore, was an hallucination or a dream, stemming from the accident he sustained at the end of Series 4. I hope so. I want the old (grumpy but sane) House back–and Amber too!!

  224. Oh shi-,
    if we now look at the facts… black tie, music during ceremony, etc…

    Could it be that House killed Chase in fact? Or perhaps even Kutner?

  225. yeah, i have no idea what happened in the end

  226. Daniel wrote:

    “2. Lack of adverse effects from strangulation, save for shortness of breath. I’ve seen this countless times: a person is strangled by a strong person, on the brink of passing out, but is saved at the last second. After a few deep breaths, they’re back to normal. In reality, putting such pressure around the neck can cause a variety of serious tissue damage, resulting in long-term damage (possibly death?). ”

    I’m not a doctor — but as a practitioner of Judo I have a great deal of real life experience both strangling others and being strangled myself.

    In my experience, if a carotid choke is applied — but released before you pass out, you will be back to normal very quickly. And what they portray on TV is fairly accurate.

    If instead, the choke hold is held until the person passes out — then there is sometimes short term memory loss (as in, not remembering why they passed out).

    There will also sometimes be spasmodic jerking — as the lack of oxygen to the brain can cause a seizure. But these seizure’s are not considered harmful — and one does recover quickly even from this. This is a not uncommon occurrence in young children through “breath holding.” As described here:
    http://www.drgreene.com/21_557.html

    Some people think that the pressure on the vagus nerve makes a carotid choke dangerous — since pressure on that nerve can slow the down the person’s heart rate. But if a person is being choked their heart rate is almost always very high and so being slowed down some would not usually be dangerous. [An important exception would be if someone was on drugs that had already dangerously lowered their heart rate.]

    Now trachea chokes are much more painful — and also take much longer to take effect. I don’t doubt that police officers can cause quite a bit of tissue damage when applying a choke from behind with a baton.

    But I assume the chokes on TV you’re referring to are being done with the bare hands, or a rope, or a length of cloth … and while I’m sure it’s possible for something to be seriously damaged — it is very unlikely.

    Now what is unrealistic about chokes on TV … is that the assailant often chokes the person until they stop moving — and then they release the choke and the victim is portrayed as having been killed. When in reality they’d just be unconscious — and would wake back up in short order and almost always would be perfectly fine. (Although, probably rather pissed that you tried to kill them ;-)

    ~ Scott

  227. All that and not a single Dr. Strangelove reference.

    Maybe they have a BSG thing going on where they are going to have head characters. Perhaps Hugh Laurie will open Season 6 with playing “All Along the Watchtower” lol.

  228. It’s tooooo late for me to post a comment. I just watched House a week ago and I’m amazed!! FYI, I dont live in US. And I started with the 4th season. Really eager to watch the early 3 seasons.

    “Can a doctor get his/her medical license again after this whole addicted problems?”

    Well, I know a doctor. He used to take some kind of opioid drugs (I dont remember the name of the drugs) and he became addicted to it. Somehow, after a long time, the hospital knew it and send him to rehab. Really hard time. After get out from the rehab, he still can do his job (as a doctor) BUT was done under trial first. That’s a bit of the reality.

    “Why house take vicodin even though he knew the effects of overusage?”

    C’mon….. House story is based on Holmes who take cocaine -sometimes morphine. Holmes use it to stimulate his brain. He just can’t let it rest.

  229. I’ve read about 80% of the posts here.. and got bored of reading same stuff over and over so .. here are my thoughts:

    1. The writers achieved what they were hoping for: they made us wonder which parts of the series were happening for real and which were just House’s hallucination.

    Seriously, is it really possible to imagine such complex scenarios without previous symptoms of either a mental illness or drug overdose? I don’t think so…

    2. Which scenes form the last few eps were real?

    Apart from hallucinating dead people i think some dialogues/scenes may have been hallucinated. Remember when Wilson says to House to make Cuddy real mad? Is this really Wilson speaking or is it a hallucination leading to House shouting about shagging Cuddy at some point in his life? There are more scenes like that which may be hallucinations leading to real events or vice versa.

    3. Does House really have schizophrenia? if he did, he would have to be on psych meds for the rest of his life. I think everyone knows which are the most common side effects of such meds..

    If it really is high levels of Vicodin, this might not come from just popping more pills. Every cell in the organism absorbs the drug and certainly the liver would act like a sponge. Maybe it started shutting down (remember the end of the “Locked In” ep when it’s impled that House may resemble the patient) slowly releasing the toxins that had accumulated over the years.

    PTSD is another explanation of course… as well as the many accidents house was involved in (you forgot him offing himself by trying to ‘kill the wall’). I ust believe his organism just gave up. Both phisically and mentally. This way he won’t be needing anti-prych meds and the rest in the institution along with some treatment might cure him.

    Another thing that’s been bothering me – end scenes: House being driven off to the clinic vs Chameron wedding. It hapened simulnaneously – just look at Cuddy having mixed feelings about where she should really be. Colour vs grey is just a cinematographic trick to evoke even stronger emotions.

  230. And sorry for so many typos..

  231. I think that the Hallucinations could have stemmed from the bus accident as well as everything he did to himself afterward (Alzheimer’s medication, deep brain stimulation, hypnosis, popping handfuls of pills, having the seizure that widened his skull fracture, etc.) If you really look at it, he was declining through the entire season, at a rate that wasn’t noticeable until you look at it as a big picture. House’s Head/Wilson’s Heart could’ve started it, or just through what the pills were doing into overdrive.

  232. I heard a rumor that for season 6, Laurie had shaved his head… could brain cancer be a possibility?… and man, what a twist at the end…

  233. Technically House didn’t lie, they slept together before he was hired.

  234. They slept with each other in high school. Someone above me probably answered the last point but I cant be bothered reading through them all.

  235. damn I meant medical school or at some earlier stage. It was mentioned in one of the other episodes that they had a one night stand.

  236. Scott:

    Thanks for the reply. I note you refer (mainly) to choke-holds used by trained people, specifically designed to subdue others without (or minimal) harm. I was referring to a situation where a strong person attempts murder by wrapping their hands around the neck of another and simply squeezing with all their might.
    I know in real life this can result in a broken hyoid bone; I thought various other serious injuries would also occur.

    Hmm, just found this link which sheds some light:
    http://www.hbo.com/autopsy/baden/qa_10.html

  237. [...] Polite Dissent » House — Episode 24 (Season 5): “Both Sides Now … [...]

  238. I know it is a little late to be adding comentary, but something struck in my mind.

    Could the hallucinations be caused by a stroke? He already threw one clot that left him without a thigh muscle. is he on anti-cloting medication? did they resolve where the frist clot came from?

    I’m not sure of the medicine on this but it seems to me that the way to left field the explainations to his having hallucinations would be to have a stroke.

    anyone elses thoughts on this?

  239. The second the scene changed and Cuddy’s clothes changed, I was like WTF? lol.. I ran it back too cuz I thought something happened with my recording. haha. I enjoyed this season a lot and can’t wait until September when it continues.

  240. I love House !!! I cried when he had to go to that hospital ….. arghhh…. I hope Cuddy and House will be together in the next season ….. love to see their attraction to one another …could se the pain n anguish in both of them !!

  241. Scott: just wondering… Would you say that House has improved your own diagnostic ability? ;)

    Not, I hasten to add, from watching the show, but from the research you have done afterwards on the way House & Co. approach the medicine?

    Thanks for your column here – always an informative joy to read.

  242. Someone else mentioned Dr. Strangelove, and I’d heard somewhere before that Alien Hand Syndrome is also referred to as Dr. Strangelove Syndrome. I, too, was disappointed at the lack of reference to it.

  243. “(though shouldn’t Cuddy have been mad that House lied to the clinic about sleeping with her, and not just yelled at him for discussing her sex-life?).”

    There are hints throughout the series that Cuddy has slept with House at some point before season 1.

  244. Only about 2 1/2 more weeks to wait for Season 6….! It’s been interesting reading the speculation here over the last many months and the amount of security to prevent plot leaks from getting on the internet has been nothing short of phenomenal as I personally have scoured the furthest reaches of the ‘net for ANY new news but have instead only found the same old news that we already know about..

    Season 6 I think will be the best season ever if the writers don’t screw things up and instead focus on House’s rehab with Cameron & Chase’s wedding as a counterpoint..

    Interesting note: What ever happened with 13’s Huntington’s(sp?) It was a major plot issue in episodes past then all of a sudden…. ‘poof’ nothing more’s been said about it…. A nice twist would be to have her condition get worse this season so that it adds drams and makes it a 3-way between house/the wedding/13’s illness….

    The wait’s almost over but MAN did it seem like forever to be able to get to this point….

  245. Saw a teaser trailer for the debut episode and all I can say is… WOW!

  246. actually, regarding what Cuddy said to House about her sex-life, maybe it is true that they had a one-night stand ages ago (read that on Wikipedia) because it was implied in Season 3. So maybe she’s just pissed he revealed that incident (or so she thought) which they most probably put behind them already.

  247. I so enjoy your postings, Scott, and I’ve gotten a kick out of reading how deeply many viewers analyze the show.

    Now I wonder if anyone is wondering the same thing I am: Will someone finally make Chase wash and comb his hair in Season 6?

  248. my family and i are completely obsessed with the show house and we’ve watched every episode (I think season 3 was best and season 5 worst). however, i did not like the ending of the finale episode of season 5. the idea of house being insane or schizophrenic or whatever didn’t appeal to me. i thought the wedding scene was really splendid though. (The whole thing with Cameron’s dead husband’s sperm drove me crazy though. why does she always have to find something to get between her and chase? i like the old team better than the new one. chase is really different since he’s not a suck-up anymore. foreman’s still cool though, and toub and 13 and kutner were pretty cool (especially toub.) but i don’t miss kutner on the show not that he went to work for obama (good for you, kal!) and 1 more thing: i think that if they continue with house being mentally ill or whatever, they should have him hallucinate himself as his sub-conscious, and not just amber. it would be cool to see 2 houses at once!

  249. sorry there was a typo on my last comment. i meant to say that “NOW that kutner went to work for obama…”

    oh and i know the whole thing with house being insane is just for a change of pace (like in season 3 with foreman and cameron quitting and chase getting fired) but still, if they want a change of pace, i could offer some better suggestions than house being insane.

    and one more thing: they should have a case where a patient has alice in wonderland syndrome. (it actually exists)

  250. ok ok i just watched a trailer of house season six, and i partially take back what i said before. IT LOOKS REALLY COOL!!!

  251. I thought it was weird how House got over detox so fast, but I just thought of it as
    bad writing or time constraints. I feel like an idiot for not realizing
    that it was another hallucination (especially since last episode I wondered why he only hallucinated of Amber). Anyways, one week till Season 6! I’ll definitely be back for more reviews (thanks for writing them, by the way)

  252. I can’t wait to see Andre Braugher as House’s doctor this season. He’s a great actor.

  253. Sharpen your pencils, Scott. Tonight is the night for the two hour season opener. Monday, September 21 at 8 pm ET.

  254. god the first episode of season 6 was so weird!! i mean, it felt like they covered ten episodes in one. and then the end with the mute girl playing violin and the superman guy being okay was just sappy and fake-looking. the thing with alvy deciding to take his meds was okay though. and i hated the whole thing with house and that woman; HE BELONGS WITH CUDDY!!!
    i wish they could just keep the show the way it used to be.

  255. SEASON SIX SPOILER…

    I found the sex scene in season six episode 1 much more believable than the one with Cuddy. When he was groping Cuddy, i had the uncomfortable feeling that he was eating her. That might’ve been done on purpose, metaphorically, since it was a hallucination.

  256. @Scott (the practitioner of Judo). Your response (229) to Daniel’s(223) is the funniest post I’ve read on this site. Made even funnier by Daniel’s attempt to redeem himself “I was refering to a strong person”. Well who gets strangled by a weak person? Lol

  257. The star of the show is Anne Dudek.

  258. Just as a note to your last bit about cuddy being mad about House ‘lying’. Well, House didn’t lie. He HAS slept with Lisa Cuddy, so what he said was true. He just meant the previous night, whereas she would’ve thought he meant a long time ago.

  259. I know, I know- I’m a bit late to the party.

    But, for what it’s worth, Anne Dudek has been incredible in this season. CTB was an interesting, great, albeit horrible character portrayed perfectly. But to go from that to House’s subconcious version- genius. I love how there’s so much of her that’s a ghost of the original Amber, but she’s so obviously part of House’s head as well. Just incredible acting. And to reiterate what has been said already, the spooky whisper-in-the-ear scene at the end- creepy, twisted, incredible perfection!!

  260. This episode just aired in the Netherlands for the first time, therefore a seemingly late reply.

    I just wanted to add that the test to see if there is communication between the left and right brain has not been done correctly. They only partly differentiate between the left and right eye, by letting the patient focus on the cross. Part of the fibers in the eye go to the left hemisphere, the other half go to the right hemisphere. You would need special lenses that shield off either the right or the left side of the visual field of one eye. By shielding one eye only, visual information still reaches both hemispheres.

  261. This is mad old but just to point out that the reason cuddy didn’t get angry with house for lying as he never said when he was supposed to have slept with her and it had already been implied they did back in college in older episodes. and then confirmed in season 6 :)

  262. Actually, “I’ve had sex with Lisa Cuddy!” is not a lie. They had dated years ago (see in season 3) and Cuddy believes House to refer to this prior affair. Hence the permanent quiproquo…

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