Comments on: House — Episode 12 (Season 6): “Moving The Chains” http://www.politedissent.com/archives/4652 a blog of medicine, comics, television, science and other fun stuff Fri, 10 Feb 2012 05:09:03 -0600 http://wordpress.org/?v=2.8.4 hourly 1 By: ecoli http://www.politedissent.com/archives/4652/comment-page-3#comment-1117916 ecoli Sat, 22 Oct 2011 11:23:50 +0000 http://www.politedissent.com/?p=4652#comment-1117916 I did not follow the medicine of the show much, but I have some concerns about the treatment of GnRH here: 1: I know that it should sometimes work like this, but Scott's line "and if that’s the case, the body generally downregulates GnRH receptors when GnRH levels are unusually high, actually leading to hypogonadism and less testosterone." is waay too paradoxical to be true. Remember, the body produces GnRH to initiate steroid production. 2: "Why would a melanoma secrete GnRH?" Well, melanoma cells are derived from the neural crest like the brain and the pituitary Not so weird for me. 3: "GnRH is released into the pituitary, not from it, so why would a pituitary cancer lead to “leaking” GnRH?" Maybe by destroying the structure of the pituitary and allowing GnRH to leak away in the bloodstream. I did not follow the medicine of the show much, but I have some concerns about the treatment of GnRH here:
1: I know that it should sometimes work like this, but Scott’s line “and if that’s the case, the body generally downregulates GnRH receptors when GnRH levels are unusually high, actually leading to hypogonadism and less testosterone.” is waay too paradoxical to be true. Remember, the body produces GnRH to initiate steroid production.
2: “Why would a melanoma secrete GnRH?” Well, melanoma cells are derived from the neural crest like the brain and the pituitary Not so weird for me.
3: “GnRH is released into the pituitary, not from it, so why would a pituitary cancer lead to “leaking” GnRH?” Maybe by destroying the structure of the pituitary and allowing GnRH to leak away in the bloodstream.

]]> By: Jeff http://www.politedissent.com/archives/4652/comment-page-3#comment-1061064 Jeff Fri, 10 Jun 2011 16:37:48 +0000 http://www.politedissent.com/?p=4652#comment-1061064 The idea that a highly-touted college prospect could lose his chance at the NFL by missing one game is ludicrous. If he's really that good, scouts will be knocking down his door. The idea that a highly-touted college prospect could lose his chance at the NFL by missing one game is ludicrous.

If he’s really that good, scouts will be knocking down his door.

]]> By: Legion http://www.politedissent.com/archives/4652/comment-page-3#comment-1043089 Legion Fri, 06 May 2011 11:46:46 +0000 http://www.politedissent.com/?p=4652#comment-1043089 Many, many good character moments in this episode, particularly the Poirot moment. I wish he spoke like that all the way through (in that scene), because unlike most actors (especially Americans, cough cough) Hugh Laurie nails that as well. He's just so damn talented. Hugh, I love you! Many, many good character moments in this episode, particularly the Poirot moment. I wish he spoke like that all the way through (in that scene), because unlike most actors (especially Americans, cough cough) Hugh Laurie nails that as well. He’s just so damn talented. Hugh, I love you!

]]> By: HouseIsMyVicodin http://www.politedissent.com/archives/4652/comment-page-3#comment-928814 HouseIsMyVicodin Mon, 20 Sep 2010 00:56:08 +0000 http://www.politedissent.com/?p=4652#comment-928814 I also thought about Lucas pretty early, he seemed the stealthy guy to be able to pull pranks like that. I would have loved to see House smashing his face :D Btw, it seldomly occurs someone taller than House is on the show. He definitely got beaten in that episode :) I also thought about Lucas pretty early, he seemed the stealthy guy to be able to pull pranks like that. I would have loved to see House smashing his face :D
Btw, it seldomly occurs someone taller than House is on the show. He definitely got beaten in that episode :)

]]> By: johnskrb http://www.politedissent.com/archives/4652/comment-page-3#comment-926436 johnskrb Fri, 17 Sep 2010 23:54:20 +0000 http://www.politedissent.com/?p=4652#comment-926436 A non-medical observation/question: Does Hollywood really believe that this man is what an offensive lineman looks like? Real collegiate offensive linemen -- especially those considered as a pro prospect -- are large, but athletic and muscular. This guy was just fat. A guy of his build could play offensive line in high school, but that is it. It ruined the show for me. A non-medical observation/question:
Does Hollywood really believe that this man is what an offensive lineman looks like?
Real collegiate offensive linemen — especially those considered as a pro prospect — are large, but athletic and muscular.

This guy was just fat. A guy of his build could play offensive line in high school, but that is it. It ruined the show for me.

]]> By: Syeve. MT, ASCP http://www.politedissent.com/archives/4652/comment-page-3#comment-812465 Syeve. MT, ASCP Sat, 17 Apr 2010 08:14:19 +0000 http://www.politedissent.com/?p=4652#comment-812465 The cryoglobulinemia would have most definitely shown up in the tubes sent to the blood bank. While I've only seen it once or twice in my career, it was immediately apparant on inspection of the sample. And even if it wasn't right away, you'd get very suspect results with a run of the mill type/screen(everything would appear positive). The cryoglobulinemia would have most definitely shown up in the tubes sent to the blood bank.

While I’ve only seen it once or twice in my career, it was immediately apparant on inspection of the sample.

And even if it wasn’t right away, you’d get very suspect results with a run of the mill type/screen(everything would appear positive).

]]> By: Caustic Guy http://www.politedissent.com/archives/4652/comment-page-3#comment-774776 Caustic Guy Wed, 24 Mar 2010 22:15:47 +0000 http://www.politedissent.com/?p=4652#comment-774776 "Increased scent and constant hyperaggression," like being one of the best in the world at knocking the snot out of people, and smelling like a locker room most of the time? A guy who's about to become a professional football player can have increased scent and hyperaggression without people suspecting a medical condition. “Increased scent and constant hyperaggression,” like being one of the best in the world at knocking the snot out of people, and smelling like a locker room most of the time?

A guy who’s about to become a professional football player can have increased scent and hyperaggression without people suspecting a medical condition.

]]> By: Melissa V. http://www.politedissent.com/archives/4652/comment-page-3#comment-764278 Melissa V. Mon, 15 Mar 2010 16:50:41 +0000 http://www.politedissent.com/?p=4652#comment-764278 They could have at least said "Hey, this is how Bob Marley died!" and made it a little more realistic, but what can you do? They could have at least said “Hey, this is how Bob Marley died!” and made it a little more realistic, but what can you do?

]]> By: Melissa V. http://www.politedissent.com/archives/4652/comment-page-3#comment-764274 Melissa V. Mon, 15 Mar 2010 16:47:05 +0000 http://www.politedissent.com/?p=4652#comment-764274 I'm sure there's been a few mentions of it already, but it does actually upset people when you diagnose someone with melanoma and then give it the ole "it's JUST skin cancer" routine. We melanoma survivors don't really like people blowing it off as non-serious, but that's the exposure they get to it. Another show had a doctor with melanoma and mets in her brain and she DIED but of course they brought her back to life, fired her, and now the character is leaving the show. Great, but that's not how stage 4 melanoma works, either. Love House, but didn't like this diagnosis. I’m sure there’s been a few mentions of it already, but it does actually upset people when you diagnose someone with melanoma and then give it the ole “it’s JUST skin cancer” routine. We melanoma survivors don’t really like people blowing it off as non-serious, but that’s the exposure they get to it.

Another show had a doctor with melanoma and mets in her brain and she DIED but of course they brought her back to life, fired her, and now the character is leaving the show. Great, but that’s not how stage 4 melanoma works, either.

Love House, but didn’t like this diagnosis.

]]> By: Anyadahalaor http://www.politedissent.com/archives/4652/comment-page-3#comment-751753 Anyadahalaor Mon, 08 Mar 2010 10:05:58 +0000 http://www.politedissent.com/?p=4652#comment-751753 Now I am a vet not an M.D., but something rather odd caught my attention during this episode. Why did they link GNRH overproduction with the guys large size? Isn't GNRH responsible for inducing FSH secretion, and the secretion whole other sexual hormones? Or is STH production related to GNRH in case of humans? Even if it were the guy would show other signs of hormone hyper-production, probably causing increased scent, and constant hyperaggression instead of the single occurrence of it. Now I am a vet not an M.D., but something rather odd caught my attention during this episode. Why did they link GNRH overproduction with the guys large size? Isn’t GNRH responsible for inducing FSH secretion, and the secretion whole other sexual hormones? Or is STH production related to GNRH in case of humans? Even if it were the guy would show other signs of hormone hyper-production, probably causing increased scent, and constant hyperaggression instead of the single occurrence of it.

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