House returns with a well done episode with some of the best medicine yet. There is a high “ick-factor” this week, so consider yourself warned when you watch the episode or when you read this week’s House medical review.
Tracy and Jeremy, a young married couple, are eating in a diner when two gunman try to rob the restaurant. Tracy is held hostage, but Jeremy manages to rescue her. After subduing the gunman, he turns around to finder her gasping for breath in anaphylactic shock.
House’s team picks up the case four days later. In addition to the swelling of her throat, Tracy is also experiencing abdominal pain. She has been on steroids and antihistamines the four days she has been in the hospital and has shown some improvement. Allergy tests were negative and a laparoscopy has already been performed and was also negative. The initial differential diagnosis is pregnancy and allergies, both of which are ruled out by testing. Her urine drug screen did show evidence of marijuana and the team speculates that she could have been exposed to Salmonella through contaminated marijuana. She is started on a fluoroquinolone (an antibiotic such as Cipro, Levaquin, or Floxin) to treat the suspected Salmonella.
She develops a rash from an allergic reaction to the antibiotic (an allergy that happened way too fast, by the way). The team now discusses allergies as a cause again, but House suspects exercise induced anaphylaxis. Tracy is placed on a treadmill. She has some abdominal pain, but the test is negative. On the other hand, her husband develops severe chest pain and abdominal pain and finds himself admitted to House’s service. His initial work-up is negative — no heart attack or aortic dissection — and the team thinks it might be psychosomatic or a panic attack.
Then the team makes the assumption that both Tracy’s and Jeremy’s conditions are related and share a common cause. It seems like quite a stretch in logic to me at this point, but it’s not my show. A search of their apartment turns up a box of condoms so Chase and House suspect the cause is Gonorrhea, but all STD tests are negative.
Tracy’s pain is worsening. She goes into acute delirium and hallucinates about Jeremy’s father. She then slips into a coma. An MRI shows some generalized swelling as well as some suspicious spots in the brain stem, but it doesn’t give enough information for a firm diagnosis. House is concerned about sarcoidosis, though he also mentions plaques (multiple scelerosis, Alzheimer’s) and tumors. He starts the pair on methotrexate to treat the presumptive sarcoidosis, but he also wants a biopsy of Tracy’s brain. This sets up an ethical dilemma. Jeremy would normally be able to make medical decisions for Tracy when she is incapacitated, but since the decision will also affect his health, there is a conflict of interest. Another guardian must be declared, but that will take time. House ignores this and sends the team to talk to Jeremy, but he refuses to let them biopsy her brain. House wants to browbeat him into agreeing, so he uses naloxone to counteract Jeremy’s pain medicine. Despite House’s ploy, he still refuses.
Jeremy is not showing any brain symptoms, but he starts showing an elevated lactic acid, which can be a sign of an ischemic bowel (intestines that are not getting enough blood supply. This can proceed to death or infection of the intestines.). The team is concerned that his bowel is dying, so they operate expecting to have to remove some bad bowel. Surprisingly, they find no dead bowel, just swelling of the intestines. House now wonders if maybe it is two separate diseases: Tracy has small cell vasculitis, while Jeremy has porphyria. He then makes one of his patented logical leaps and realizes that they both have a rare genetic disorder called Hereditary Angioedema that leads to the swelling of body tissues, particularly in times of stress. He then takes it one step farther and realizes that Tracy and Jeremy share the same father and are in fact half-siblings, this giving us our ick-factor of the episode.
Overall, the medicine was sound. I have a few complaints, most of which I mentioned above, but no deal breakers this week. Most of the mistakes were jumping to conclusions too quickly without any real evidence, but that’s par for the course on this show. The team also went to surgery too quickly, both on Tracy’s laparoscopy (though that was the previous team), and on Jeremy’s bowel surgery. (And why didn’t they see edema during Tracy’s surgery?). I feel I should point out that the Young Guns did not perform any unrealistic testing themselves this week (the treadmill was a test I would expect them to run); since I always criticize them in this area, I will compliment them for getting it right this week. Additionally, lupus was not mentioned this week, nor was “autoimmune disease.”
Some nice soap opera this week. All three of the Young Guns, particularly Foreman, are standing up to House more. There is a clever sub-plot involving Wilson and a pediatric nurse, as well as House’s continues insistence that Cuddy is pregnant. David Morse also appears as a taciturn and disgruntled patient of House. He lodges a complaint, but House rebuffs him. In the final scene, House is speeding down the street on his motorcycle when he is pulled over by a cop — one that just happens to be Morse. House ends up arrested for possession of narcotics (this scene would have had a lot more punch if FOX hadn’t spoiled it by showing it in every preview for the past month).
I give this episode a B for the mystery, but an A for the solution because it was clever and supported by the signs and symptoms of the patients. Surprisingly, I award the medicine an A — a weak A, but an A nonetheless. The soap opera/non-medical aspect was good and deserve a B+.
The previous House review
A list of all prior House reviews
Tags: television medicine house sarcoidosis angioedema.