An…interesting…episode with two patients: a depressed teen-age boy with a bleeding problem, and Cuddy. There were some clever moments (for instance, now I really want to see Hugh Laurie’s take on the emcee from Cabaret
), but ultimately the medicine had too many mistakes and required too much handwaving to work

I. Ryan
Ryan is a 16 year-old adolescent who is admitted to the hospital after spitting up blood during a pick-up basketball game. His pulmonary and GI work-ups were negative, so he is admitted to House’s team for evaluation. Initial concerns include vasculitis (blood vessel inflammation), bronchiectasis (chronic airway damage and scarring), inhaled particles, or angiodysplasia (abnormal blood vessels in the gastrointestinal tract). House favors the latter, so he has the patient swallow a special camera to look for angiodysplasia. The study is negative. Meanwhile, Taub confronts Ryan about cutting, given the healing cuts on his abdomen. Ryan denies the cutting, telling Taub the wounds are from a skateboarding injury. Taub then points out that Ryan has many of the signs and symptoms of depression, which Ryan ultimately admits to. He also admits to smoking marijuana, which Taub thinks may have been contaminated with lead or formaldehyde, leading to the Ryan’s symptoms. A lead level is checked (and apparently normal, as it is never mentioned again).
Ryan now has developed some red spots — small hemorrhages — in his eyes. This is his second bleeding-related symptom, so the team now considers an acquired coagulopathy or a Staph infection. House thinks the infection is more likely, so Ryan is started on Nafcillin (a good anti-Staph antibiotic). Despite the new treatment, Ryan’s symptoms worsen. He starts seeing blood in his urine, and a subsequent kidney scan reveals a mass of some sort. The differential diagnosis now consists of antiphospholipid syndrome or a heroin-induced nephropathy (kidney damage caused by heroin use). To House, the first seems the more logical choice, so Ryan is started on plasmapheresis. Taub and Foreman search Ryan’s home and find no illegal drugs, but do find that he has defaced his yearbook with threats to kill half his class. The two return to the hospital when they learn Ryan’s right arm has gone numb. Foreman now suspects that instead of a bleeding problem, Ryan actually has a clotting problem. He gets an angiogram of the brain and sure enough, it shows a clot. Ryan is started on Streptokinase (a thrombolytic, or “clot busting” drug), but doesn’t improve. The team decides to proceed with an embolectomy — advancing a catheter into the arteries of the brain to remove the clot — but the clot disintegrates in the middle of the procedure just as Foreman reaches it. To complicate the situation, Taub has found videos of Ryan’s that show him detonating pipe bombs while making threatening comments. He is unsure who in authority, if anyone, he should tell.
Ryan continues to get worse. Out of nowhere, he’s now in a coma, on a mechanical ventilator, and his liver is failing. Because House is obsessing over Cuddy, the team is on their own and looking at such diagnoses as AIP (acute intermittent porphyria) and fucosidosis (an inherited enzyme deficiency) before settling on type II citrullinemia (another enzyme deficiency — in the case of type II citrullinemia, almost entirely exclusive to Japanese patients). They start him on sodium benzoate to treat the suspected high ammonia levels (which would be easy to test for, hint, hint). Across the hospital, House is having a conversation with Cuddy when he has his Eureka! moment. He realized that Ryan has a Staph abscess, and while the antibiotics given earlier treated the bacteria in the blood, they did not reach the ones still protected in the abscess. Taub takes it a step further and realizes that the likely source of the abscess is the pipe bombs Ryan had been making, and the cuts on his abdomen are shrapnel wounds, not skateboarding injuries. Some PVC fragments got in his body, picking up Staph along the way, and developed into abscesses. Apparently these abscesses now are somehow breaking apart, and sending septic clots throughout the body, causing all Ryan’s other symptoms. After some surgery to open the abscesses and remove the shrapnel, and loads more antibiotics, Ryan should be good as new — physically.
II. Cuddy
Out of the blue one morning, Cuddy sees blood in her urine. Next thing that morning, she has a cystoscopy performed, which shows nothing abnormal. She proceeds to a renal (kidney) ultrasound — performed by Wilson (who is apparently an ultrasound tech and radiologist in addition to being the New Jersey’s top oncologist) – which shows a mass in her kidney. A biopsy of the mass is obtained, but it is inconclusive. Further radiology shows enhancing lesions in her lungs, which makes everyone suspicious for metastasized renal cancer. Now she definitely needs a surgical biopsy. The mass is removed and turns out to be a benign oncocytoma. The masses in her lungs? Those were an allergic reaction the antibiotics she was on. All’s well that end’s well — physically.
As usual, major complaints are in red, modest complaints are in blue, and nit-picking ones in green:
Except for a rare condition or two that combine clotting and bleeding (DIC — disseminated intravascular coagulation, comes to mind), clotting disorders and bleeding disorders are distinct entities and very different (and you’ll notice they never tested for DIC or anything similar). Bleeding disorders do not present as clotting disorders and vice versa.
Streptokinase is a first generation thrombolytic — in a cutting edge hospital, why would Foreman choose to use it instead of a newer agent, especially when he is a Neurologist and should know streptokinase has been shown not to be beneficial (and thus not approved) for use in strokes.
Contraindications to the use of streptokinase include recent bleeding problems. Ryan has a condition which has caused at least three unexplained bleeding episodes, and now they want to give him a drug which will likely cause him to bleed more? It’s not an absolute contraindication, just a relative one, but still, they should have at least mentioned it, or gone straight to the embolectomy.
If streptokinase doesn’t work, you don’t just “increase the dose.”
Taub is correct that most PVC — unless specially treated — will not show up on x-ray or CT scan. However, the abscesses themselves still should.
The PVC would, however, show up on ultrasound.
I’m unclear how the abscess is breaking apart enough to cause clots elsewhere in the body. If it is walled off enough to prevent antibiotics from reaching it, it shouldn’t be breaking up into the blood stream.
Cuddy’s sleeping pill label read “Zolpidem, 200MG.” Zolpidem is better known as Ambien — the maximum dose of which is 10MG. She is taking twenty times the maximum dose (and no, it doesn’t come in 200mg capsules — only in 5 and 10MG pills).
Antiphospholipid Syndrome is a clotting disorder, not a bleeding disorder.
For the first time all season, they never checked blood cultures?
Ryan is so depressed he’s playing pick-up basketball games?
Plasmapheresis is not the first-line treatment for antiphospholipid syndrome.
This week’s medical mystery started a little bland, but picked up speed, but then they started throwing everything at it (out of nowhere a coma! And liver failure!). I give it a B-. The final solution was a stretch and the writers are trying to have it both ways: the abscesses are walled off and protected from the body, but no they’re causing problems in the body — everywhere! I give it a C-. The medicine was sloppy (confusing a clotting and a bleeding disorder?) and conveniently neglected tests they’ve run in every other single episode. It also earns a C-. The soap opera was certainly inventive, which I give them credit for. It also advanced the overall plot, which I appreciate. I give it a B+.
This week’s House Challenge scores have been posted.
The review of the previous episode of House
A list of all prior House reviews